PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDY
In Lebanon, clinical information about community-acquired urinary tract infections (CAUTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Gram negative bacteria (GNB), is scarce. A population based case-control study was conductedwhereby42 cases were matched to 42 controls. The preva...
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| Format: | Article |
| Language: | English |
| Published: |
Associazione Italiana Giovani Medici
2016-04-01
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| Series: | Euromediterranean Biomedical Journal |
| Online Access: | http://www.embj.org/images/ISSUE_2016/bou%20assi_21.pdf |
| Summary: | In Lebanon, clinical information about community-acquired urinary tract infections
(CAUTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Gram negative
bacteria (GNB), is scarce. A population based case-control study was conductedwhereby42
cases were matched to 42 controls. The prevalence of ESBL producing
strains was 14.15%. Univariate analysis showed two statistically significant independent
risk factors for ESBL producing strains: antibiotic use during the last three months
(p<0.0001), and urinary catheterization during the last six months (p=0.0034); and
one protective factor: age group 18-50 years (p=0.011). Multivariate analysis showed
antibiotic use as the strongest predictor for CAUTI due to ESBL-producing GNB. Coresistance
of ESBL producing strains to antibiotics was significantly higher compared
with non ESBL strains: ciprofloxacin (75% vs 21.4%), trimethropin-sulfamethoxazole
(71.1% vs 35.7%) and amoxicillin-clavulanate (77.7% vs 9.5%).This study confirms
that ESBL-producing GNB strains constitute a notable cause of CAUTI in Lebanon.
These results can be used to guide appropriate treatment of CAUTI and targeted infection
control measures. |
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| ISSN: | 2279-7165 2279-7165 |