PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDY
In Lebanon, clinical information about community-acquired urinary tract infections (CAUTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Gram negative bacteria (GNB), is scarce. A population based case-control study was conductedwhereby42 cases were matched to 42 controls. The preva...
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| Format: | Article |
| Language: | English |
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Associazione Italiana Giovani Medici
2016-04-01
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| Series: | Euromediterranean Biomedical Journal |
| Online Access: | http://www.embj.org/images/ISSUE_2016/bou%20assi_21.pdf |
| _version_ | 1818054626393456640 |
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| author | Elie EL-HAJJ |
| author_facet | Elie EL-HAJJ |
| author_sort | Elie EL-HAJJ |
| collection | DOAJ |
| description | In Lebanon, clinical information about community-acquired urinary tract infections
(CAUTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Gram negative
bacteria (GNB), is scarce. A population based case-control study was conductedwhereby42
cases were matched to 42 controls. The prevalence of ESBL producing
strains was 14.15%. Univariate analysis showed two statistically significant independent
risk factors for ESBL producing strains: antibiotic use during the last three months
(p<0.0001), and urinary catheterization during the last six months (p=0.0034); and
one protective factor: age group 18-50 years (p=0.011). Multivariate analysis showed
antibiotic use as the strongest predictor for CAUTI due to ESBL-producing GNB. Coresistance
of ESBL producing strains to antibiotics was significantly higher compared
with non ESBL strains: ciprofloxacin (75% vs 21.4%), trimethropin-sulfamethoxazole
(71.1% vs 35.7%) and amoxicillin-clavulanate (77.7% vs 9.5%).This study confirms
that ESBL-producing GNB strains constitute a notable cause of CAUTI in Lebanon.
These results can be used to guide appropriate treatment of CAUTI and targeted infection
control measures. |
| first_indexed | 2024-12-10T12:00:02Z |
| format | Article |
| id | doaj.art-ac12e7cd438541f78cf1a4168ce4c476 |
| institution | Directory Open Access Journal |
| issn | 2279-7165 2279-7165 |
| language | English |
| last_indexed | 2024-12-10T12:00:02Z |
| publishDate | 2016-04-01 |
| publisher | Associazione Italiana Giovani Medici |
| record_format | Article |
| series | Euromediterranean Biomedical Journal |
| spelling | doaj.art-ac12e7cd438541f78cf1a4168ce4c4762022-12-22T01:49:40ZengAssociazione Italiana Giovani MediciEuromediterranean Biomedical Journal2279-71652279-71652016-04-01112114815610.3269/1970-5492.2016.11.21PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDYElie EL-HAJJ0University of BeirutIn Lebanon, clinical information about community-acquired urinary tract infections (CAUTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Gram negative bacteria (GNB), is scarce. A population based case-control study was conductedwhereby42 cases were matched to 42 controls. The prevalence of ESBL producing strains was 14.15%. Univariate analysis showed two statistically significant independent risk factors for ESBL producing strains: antibiotic use during the last three months (p<0.0001), and urinary catheterization during the last six months (p=0.0034); and one protective factor: age group 18-50 years (p=0.011). Multivariate analysis showed antibiotic use as the strongest predictor for CAUTI due to ESBL-producing GNB. Coresistance of ESBL producing strains to antibiotics was significantly higher compared with non ESBL strains: ciprofloxacin (75% vs 21.4%), trimethropin-sulfamethoxazole (71.1% vs 35.7%) and amoxicillin-clavulanate (77.7% vs 9.5%).This study confirms that ESBL-producing GNB strains constitute a notable cause of CAUTI in Lebanon. These results can be used to guide appropriate treatment of CAUTI and targeted infection control measures.http://www.embj.org/images/ISSUE_2016/bou%20assi_21.pdf |
| spellingShingle | Elie EL-HAJJ PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDY Euromediterranean Biomedical Journal |
| title | PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDY |
| title_full | PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDY |
| title_fullStr | PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDY |
| title_full_unstemmed | PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDY |
| title_short | PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDY |
| title_sort | prevalence and risk factors of extended spectrum beta lactamase organisms in community acquired urinary tract infections in lebanon a case control study |
| url | http://www.embj.org/images/ISSUE_2016/bou%20assi_21.pdf |
| work_keys_str_mv | AT elieelhajj prevalenceandriskfactorsofextendedspectrumbetalactamaseorganismsincommunityacquiredurinarytractinfectionsinlebanonacasecontrolstudy |