Insulators target active genes to transcription factories and polycomb-repressed genes to polycomb bodies.

Insulators target active genes to transcription factories and polycomb-repressed genes to polycomb bodies.

Polycomb bodies are foci of Polycomb proteins in which different Polycomb target genes are thought to co-localize in the nucleus, looping out from their chromosomal context. We have shown previously that insulators, not Polycomb response elements (PREs), mediate associations among Polycomb Group (Pc...

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Bibliographic Details
Main Authors: Hua-Bing Li, Katsuhito Ohno, Hongxing Gui, Vincenzo Pirrotta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3630138?pdf=render

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