Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics

Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics

The cystine/glutamate antiporter system xc− (Sxc−) belongs to the SLC7 family of plasma membrane transporters. It exports intracellular glutamate along the latter’s concentration gradient as a driving force for cellular uptake of cystine. Once imported, cystine is mainly used for the production of g...

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Bibliographic Details
Main Authors: Tran Dieu Hang, Huynh Minh Hung, Pauline Beckers, Nathalie Desmet, Mohamed Lamrani, Ann Massie, Emmanuel Hermans, Kenno Vanommeslaeghe
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
cystine/glutamate antiporter
SLC7A11 (xCT)
Sxc -
molecular dynamics simulation
homology modeling
inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1064199/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1064199/full

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