Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease.
Mutations in the GBA1 gene cause the lysosomal storage disorder Gaucher disease (GD) and are the greatest known genetic risk factors for Parkinson's disease (PD). Communication between the gut and brain and immune dysregulation are increasingly being implicated in neurodegenerative disorders su...
Main Authors: | Magda L Atilano, Alexander Hull, Catalina-Andreea Romila, Mirjam L Adams, Jacob Wildfire, Enric Ureña, Miranda Dyson, Jorge Ivan-Castillo-Quan, Linda Partridge, Kerri J Kinghorn |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-12-01
|
Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1011063 |
Similar Items
-
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila
by: Magda L Atilano, et al.
Published: (2021-03-01) -
Gaucher Disease and Gaucher Cells
by: Sevgi Gözdaşoğlu
Published: (2015-05-01) -
Neuropathological Features of Gaucher Disease and Gaucher Disease with Parkinsonism
by: Makaila L. Furderer, et al.
Published: (2022-05-01) -
Gaucher Cells or Pseudo-Gaucher Cells: That's the Question
by: Deniz Gören Şahin, et al.
Published: (2014-12-01) -
Doença de Gaucher.
by: L P Trindade e Silva, et al.
Published: (2007-04-01)