Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications
The goal of regenerative medicine is to achieve tissue regeneration. In the past, commonly used techniques included autologous or allogeneic transplantation and stem cell therapy, which have limitations, such as a lack of donor sites in the case of autologous transplantation and the invasiveness of...
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MDPI AG
2023-08-01
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| Online Access: | https://www.mdpi.com/2073-4425/14/9/1669 |
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| author | Laura Giannotti Benedetta Di Chiara Stanca Francesco Spedicato Paola Nitti Fabrizio Damiano Christian Demitri Nadia Calabriso Maria Annunziata Carluccio Andrea Palermo Luisa Siculella Eleonora Stanca |
| author_facet | Laura Giannotti Benedetta Di Chiara Stanca Francesco Spedicato Paola Nitti Fabrizio Damiano Christian Demitri Nadia Calabriso Maria Annunziata Carluccio Andrea Palermo Luisa Siculella Eleonora Stanca |
| author_sort | Laura Giannotti |
| collection | DOAJ |
| description | The goal of regenerative medicine is to achieve tissue regeneration. In the past, commonly used techniques included autologous or allogeneic transplantation and stem cell therapy, which have limitations, such as a lack of donor sites in the case of autologous transplantation and the invasiveness of stem cell harvesting. In recent years, research has, therefore, focused on new and less invasive strategies to achieve tissue regeneration. A step forward in this direction has been made with the development of autologous platelet concentrates (APCs), which are derived from the patient’s own blood. They can be classified into three generations: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factors (CGFs). These APCs have different structural characteristics, depending on the distinctive preparation method, and contain platelets, leukocytes, and multiple growth factors, including those most involved in regenerative processes. The purpose of this review is to clarify the most used techniques in the field of regenerative medicine in recent years, comparing the different types of APCs and analyzing the preparation protocols, the composition of the growth factors, the level of characterization achieved, and their clinical applications to date. |
| first_indexed | 2024-03-10T22:43:39Z |
| format | Article |
| id | doaj.art-ac15a2f1948a48ea98d7675546739125 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T22:43:39Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ac15a2f1948a48ea98d76755467391252023-11-19T10:52:02ZengMDPI AGGenes2073-44252023-08-01149166910.3390/genes14091669Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical ApplicationsLaura Giannotti0Benedetta Di Chiara Stanca1Francesco Spedicato2Paola Nitti3Fabrizio Damiano4Christian Demitri5Nadia Calabriso6Maria Annunziata Carluccio7Andrea Palermo8Luisa Siculella9Eleonora Stanca10Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, ItalyDepartment of Engineering for Innovation, University of Salento, 73100 Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, ItalyDepartment of Engineering for Innovation, University of Salento, 73100 Lecce, ItalyNational Research Council (CNR), Institute of Clinical Physiology (IFC), 73100 Lecce, ItalyNational Research Council (CNR), Institute of Clinical Physiology (IFC), 73100 Lecce, ItalyImplant Dentistry College of Medicine and Dentistry, Birmingham B4 6BN, UKDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, ItalyThe goal of regenerative medicine is to achieve tissue regeneration. In the past, commonly used techniques included autologous or allogeneic transplantation and stem cell therapy, which have limitations, such as a lack of donor sites in the case of autologous transplantation and the invasiveness of stem cell harvesting. In recent years, research has, therefore, focused on new and less invasive strategies to achieve tissue regeneration. A step forward in this direction has been made with the development of autologous platelet concentrates (APCs), which are derived from the patient’s own blood. They can be classified into three generations: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factors (CGFs). These APCs have different structural characteristics, depending on the distinctive preparation method, and contain platelets, leukocytes, and multiple growth factors, including those most involved in regenerative processes. The purpose of this review is to clarify the most used techniques in the field of regenerative medicine in recent years, comparing the different types of APCs and analyzing the preparation protocols, the composition of the growth factors, the level of characterization achieved, and their clinical applications to date.https://www.mdpi.com/2073-4425/14/9/1669autologous platelet concentratesregenerative medicinetissue regenerationgrowth factorsstem cells |
| spellingShingle | Laura Giannotti Benedetta Di Chiara Stanca Francesco Spedicato Paola Nitti Fabrizio Damiano Christian Demitri Nadia Calabriso Maria Annunziata Carluccio Andrea Palermo Luisa Siculella Eleonora Stanca Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications Genes autologous platelet concentrates regenerative medicine tissue regeneration growth factors stem cells |
| title | Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications |
| title_full | Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications |
| title_fullStr | Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications |
| title_full_unstemmed | Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications |
| title_short | Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications |
| title_sort | progress in regenerative medicine exploring autologous platelet concentrates and their clinical applications |
| topic | autologous platelet concentrates regenerative medicine tissue regeneration growth factors stem cells |
| url | https://www.mdpi.com/2073-4425/14/9/1669 |
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