Epithelial–Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress

Epithelial–Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress

Epithelial–mesenchymal transition (EMT) is implicated in tumor metastasis and therapeutic resistance. It remains a challenge to target cancer cells that have undergone EMT. The Snail family of key EMT-inducing transcription factors directly binds to and transcriptionally represses not only epithelia...

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Bibliographic Details
Main Authors: Mingwei Liang, Jennifer W. Li, Huacheng Luo, Sarah Lulu, Ozlem Calbay, Anitha Shenoy, Ming Tan, Brian K. Law, Shuang Huang, Tsan Sam Xiao, Hao Chen, Lizi Wu, Jia Chang, Jianrong Lu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
cancer
EMT
AMPK
energy stress
metformin
pyroptosis
Online Access:https://www.mdpi.com/2073-4409/11/14/2208

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