In Silico Protocol for structure and function prediction of proteins in biological systems
Proteins carry out the majority of the biological processes of living cells. These macromolecules are almost involved in every cellular process: replication and transcription of DNA, and produce, process, and biosynthesize other proteins. They are controlling cell division, metabolism, and materials...
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| Format: | Article |
| Language: | English |
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International Academy of Ecology and Environmental Sciences
2023-12-01
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| Series: | Network Biology |
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| Online Access: | http://www.iaees.org/publications/journals/nb/articles/2023-13(4)/In-Silico-Protocol-for-structure-and-function-prediction.pdf |
| _version_ | 1797633088546668544 |
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| author | Mohamed Ragab Abdel Gawwad |
| author_facet | Mohamed Ragab Abdel Gawwad |
| author_sort | Mohamed Ragab Abdel Gawwad |
| collection | DOAJ |
| description | Proteins carry out the majority of the biological processes of living cells. These macromolecules are almost involved in every cellular process: replication and transcription of DNA, and produce, process, and biosynthesize other proteins. They are controlling cell division, metabolism, and materials and information transportation into and out of the cell. The understanding how living cells work requires revealing the structure and function of proteins. Our protocol aim is to analyze protein(s) structure and its function in biological systems. There are 9 steps of the protocol by which the protein(s) is extensively analyzed structurally and functionally. These steps are bioinformatics tools and software: Retrieving sequence of protein(s), Sequence alignment, Phylogenetic tree construction, Protein(s) 3D Structure Prediction and Refinement, Protein(s) 3D structure validation and visualization, Protein(s) Domain Identification, Subcellular Localization of Protein(s) and Interactome Analysis. The protocol links between the structure and function of the protein(s) and a heuristic to predict protein(s) function. |
| first_indexed | 2024-03-11T11:45:50Z |
| format | Article |
| id | doaj.art-ac1773f2a802425d8f1697044b6244ee |
| institution | Directory Open Access Journal |
| issn | 2220-8879 |
| language | English |
| last_indexed | 2024-03-11T11:45:50Z |
| publishDate | 2023-12-01 |
| publisher | International Academy of Ecology and Environmental Sciences |
| record_format | Article |
| series | Network Biology |
| spelling | doaj.art-ac1773f2a802425d8f1697044b6244ee2023-11-09T12:00:05ZengInternational Academy of Ecology and Environmental SciencesNetwork Biology2220-88792023-12-01134186191In Silico Protocol for structure and function prediction of proteins in biological systemsMohamed Ragab Abdel Gawwad0Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo, Bosnia and HerzegovinaProteins carry out the majority of the biological processes of living cells. These macromolecules are almost involved in every cellular process: replication and transcription of DNA, and produce, process, and biosynthesize other proteins. They are controlling cell division, metabolism, and materials and information transportation into and out of the cell. The understanding how living cells work requires revealing the structure and function of proteins. Our protocol aim is to analyze protein(s) structure and its function in biological systems. There are 9 steps of the protocol by which the protein(s) is extensively analyzed structurally and functionally. These steps are bioinformatics tools and software: Retrieving sequence of protein(s), Sequence alignment, Phylogenetic tree construction, Protein(s) 3D Structure Prediction and Refinement, Protein(s) 3D structure validation and visualization, Protein(s) Domain Identification, Subcellular Localization of Protein(s) and Interactome Analysis. The protocol links between the structure and function of the protein(s) and a heuristic to predict protein(s) function.http://www.iaees.org/publications/journals/nb/articles/2023-13(4)/In-Silico-Protocol-for-structure-and-function-prediction.pdfproteomics3d structure predictionbioinformatics |
| spellingShingle | Mohamed Ragab Abdel Gawwad In Silico Protocol for structure and function prediction of proteins in biological systems Network Biology proteomics 3d structure prediction bioinformatics |
| title | In Silico Protocol for structure and function prediction of proteins in biological systems |
| title_full | In Silico Protocol for structure and function prediction of proteins in biological systems |
| title_fullStr | In Silico Protocol for structure and function prediction of proteins in biological systems |
| title_full_unstemmed | In Silico Protocol for structure and function prediction of proteins in biological systems |
| title_short | In Silico Protocol for structure and function prediction of proteins in biological systems |
| title_sort | in silico protocol for structure and function prediction of proteins in biological systems |
| topic | proteomics 3d structure prediction bioinformatics |
| url | http://www.iaees.org/publications/journals/nb/articles/2023-13(4)/In-Silico-Protocol-for-structure-and-function-prediction.pdf |
| work_keys_str_mv | AT mohamedragababdelgawwad insilicoprotocolforstructureandfunctionpredictionofproteinsinbiologicalsystems |