Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus
Biased memory processing contributes to the development and exacerbation of depression, and thus could represent a potential therapeutic target for stress-induced mental disorders. Synchronized spikes in hippocampal neurons, corresponding to sharp wave ripples (SWRs), may play a crucial role in memo...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of Pharmacological Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861323000245 |
| _version_ | 1797830048617594880 |
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| author | Hiromi Shiozaki Nahoko Kuga Tasuku Kayama Yuji Ikegaya Takuya Sasaki |
| author_facet | Hiromi Shiozaki Nahoko Kuga Tasuku Kayama Yuji Ikegaya Takuya Sasaki |
| author_sort | Hiromi Shiozaki |
| collection | DOAJ |
| description | Biased memory processing contributes to the development and exacerbation of depression, and thus could represent a potential therapeutic target for stress-induced mental disorders. Synchronized spikes in hippocampal neurons, corresponding to sharp wave ripples (SWRs), may play a crucial role in memory reactivation. In this study, we showed that the frequency of SWRs increased in the ventral hippocampus, but not in the dorsal hippocampus, after stress exposure. Administration of the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine inhibited the generation of ventral hippocampal SWRs and reduced locomotor activity and local field potential power in the gamma bands. These results suggest that the antidepressant effects of SSRIs may be mediated by the suppression of ventral hippocampal SWRs. |
| first_indexed | 2024-04-09T13:31:02Z |
| format | Article |
| id | doaj.art-ac17bbbf14454f0e83100b14df5e1ff1 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-09T13:31:02Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-ac17bbbf14454f0e83100b14df5e1ff12023-05-10T04:18:45ZengElsevierJournal of Pharmacological Sciences1347-86132023-06-011522136143Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampusHiromi Shiozaki0Nahoko Kuga1Tasuku Kayama2Yuji Ikegaya3Takuya Sasaki4Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, JapanDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan; Corresponding author.Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, JapanGraduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Center for Information and Neural Networks, 1-4 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Institute for AI and Beyond, The University of Tokyo, Tokyo 113-0033, JapanDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Corresponding author. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan.Biased memory processing contributes to the development and exacerbation of depression, and thus could represent a potential therapeutic target for stress-induced mental disorders. Synchronized spikes in hippocampal neurons, corresponding to sharp wave ripples (SWRs), may play a crucial role in memory reactivation. In this study, we showed that the frequency of SWRs increased in the ventral hippocampus, but not in the dorsal hippocampus, after stress exposure. Administration of the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine inhibited the generation of ventral hippocampal SWRs and reduced locomotor activity and local field potential power in the gamma bands. These results suggest that the antidepressant effects of SSRIs may be mediated by the suppression of ventral hippocampal SWRs.http://www.sciencedirect.com/science/article/pii/S1347861323000245AntidepressantSelective serotonin reuptake inhibitorVentral hippocampusSharp wave rippleDepression |
| spellingShingle | Hiromi Shiozaki Nahoko Kuga Tasuku Kayama Yuji Ikegaya Takuya Sasaki Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus Journal of Pharmacological Sciences Antidepressant Selective serotonin reuptake inhibitor Ventral hippocampus Sharp wave ripple Depression |
| title | Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus |
| title_full | Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus |
| title_fullStr | Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus |
| title_full_unstemmed | Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus |
| title_short | Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus |
| title_sort | selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus |
| topic | Antidepressant Selective serotonin reuptake inhibitor Ventral hippocampus Sharp wave ripple Depression |
| url | http://www.sciencedirect.com/science/article/pii/S1347861323000245 |
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