Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India
Abstract Background Cognitive impairment mainly affects learning and problem solving abilities of the person. Traditional medicines, due to fewer side effects, more efficacy and lesser cost are still the choice of treatment in India. The main objective of the present study is to explore the nootropi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-07-01
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| Series: | Clinical Phytoscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40816-021-00300-5 |
| _version_ | 1818657943902486528 |
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| author | Sapna Saini Manjusha Choudhary Ankur Garg |
| author_facet | Sapna Saini Manjusha Choudhary Ankur Garg |
| author_sort | Sapna Saini |
| collection | DOAJ |
| description | Abstract Background Cognitive impairment mainly affects learning and problem solving abilities of the person. Traditional medicines, due to fewer side effects, more efficacy and lesser cost are still the choice of treatment in India. The main objective of the present study is to explore the nootropic potential of ethanol extract of Elettaria cardamomum Maton fruits. The present study was conducted by using exteroceptive behavioral models like elevated plus maze, passive avoidance apparatus and object recognition task at doses 100, 300 and 500 mg/kg. Results Ethanol extract of E. cardamomum fruits significantly decreased transfer latency and increased step down latency and discrimination index respectively when compared to normal control groups. Piracetam and diazepam exhibited respective rise and fall in memory of the animals. The effect of plant extract on total serum cholesterol, acetylcholinesterase and malondialdehyde were more effective at two higher doses. However, it decreased serum glucose levels insignificantly whereas a significant rise in brain GSH levels was observed with increasing dose of the extract. Conclusions The study concludes that the nootropic effect of ethanol extract may be attributable to its anti-oxidant, anti-cholinesterase and cholesterol as well as glucose lowering potential. |
| first_indexed | 2024-12-17T03:49:31Z |
| format | Article |
| id | doaj.art-ac182d1c42784d139425ffd9b39b173f |
| institution | Directory Open Access Journal |
| issn | 2199-1197 |
| language | English |
| last_indexed | 2024-12-17T03:49:31Z |
| publishDate | 2021-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Clinical Phytoscience |
| spelling | doaj.art-ac182d1c42784d139425ffd9b39b173f2022-12-21T22:04:47ZengSpringerOpenClinical Phytoscience2199-11972021-07-01711910.1186/s40816-021-00300-5Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of IndiaSapna Saini0Manjusha Choudhary1Ankur Garg2Institute of Pharmaceutical Sciences, Kurukshetra UniversityInstitute of Pharmaceutical Sciences, Kurukshetra UniversityInstitute of Pharmaceutical Sciences, Kurukshetra UniversityAbstract Background Cognitive impairment mainly affects learning and problem solving abilities of the person. Traditional medicines, due to fewer side effects, more efficacy and lesser cost are still the choice of treatment in India. The main objective of the present study is to explore the nootropic potential of ethanol extract of Elettaria cardamomum Maton fruits. The present study was conducted by using exteroceptive behavioral models like elevated plus maze, passive avoidance apparatus and object recognition task at doses 100, 300 and 500 mg/kg. Results Ethanol extract of E. cardamomum fruits significantly decreased transfer latency and increased step down latency and discrimination index respectively when compared to normal control groups. Piracetam and diazepam exhibited respective rise and fall in memory of the animals. The effect of plant extract on total serum cholesterol, acetylcholinesterase and malondialdehyde were more effective at two higher doses. However, it decreased serum glucose levels insignificantly whereas a significant rise in brain GSH levels was observed with increasing dose of the extract. Conclusions The study concludes that the nootropic effect of ethanol extract may be attributable to its anti-oxidant, anti-cholinesterase and cholesterol as well as glucose lowering potential.https://doi.org/10.1186/s40816-021-00300-5Elettaria cardamomumMemoryCognitive impairmentAmnesia: Nootropics |
| spellingShingle | Sapna Saini Manjusha Choudhary Ankur Garg Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India Clinical Phytoscience Elettaria cardamomum Memory Cognitive impairment Amnesia: Nootropics |
| title | Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India |
| title_full | Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India |
| title_fullStr | Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India |
| title_full_unstemmed | Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India |
| title_short | Investigation of nootropic potential of ethanol extract of Elettaria cardamomum Maton fruit (Cardamom): a spice of India |
| title_sort | investigation of nootropic potential of ethanol extract of elettaria cardamomum maton fruit cardamom a spice of india |
| topic | Elettaria cardamomum Memory Cognitive impairment Amnesia: Nootropics |
| url | https://doi.org/10.1186/s40816-021-00300-5 |
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