Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection
Background: Helicobacter pylori eradication rates achieved with clarithromycin-based triple therapies are declining due to antibiotic resistance, but data regarding temporal changes in efficacy with these eradication therapies are scarce. Objective: To evaluate the efficacy of clarithromycin-based t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-06-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/17562848231167284 |
| _version_ | 1797796815127445504 |
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| author | Steven F. Moss William D. Chey Patrick Daniele Corey Pelletier Rinu Jacob Gabriel Tremblay Elizabeth Hubscher Eckhard Leifke Peter Malfertheiner |
| author_facet | Steven F. Moss William D. Chey Patrick Daniele Corey Pelletier Rinu Jacob Gabriel Tremblay Elizabeth Hubscher Eckhard Leifke Peter Malfertheiner |
| author_sort | Steven F. Moss |
| collection | DOAJ |
| description | Background: Helicobacter pylori eradication rates achieved with clarithromycin-based triple therapies are declining due to antibiotic resistance, but data regarding temporal changes in efficacy with these eradication therapies are scarce. Objective: To evaluate the efficacy of clarithromycin-based triple eradication regimens over time. Design: A comprehensive literature review and time-trend analysis. Data sources and methods: Bibliographies of recently published systematic literature reviews were searched and supplemented with a targeted literature review conducted using Medline and Embase databases and ProQuest from conception to May 2021. Studies reporting H. pylori eradication rates of clarithromycin-based triple therapies were included and temporal trends were estimated using a random-effects model. Results: Eradication rates for triple therapies containing proton pump inhibitors (PPIs), clarithromycin, and amoxicillin showed a significant decline over the past 23 years ( p = 0.0315). However, this decline was not significant when eradication rates achieved with vonoprazan-based triple therapy were included ( p = 0.3910). Conclusion: Vonoprazan-based triple therapy partially mitigated the decline in eradication rates seen with PPI-based triple therapy, likely due to more powerful acid suppression of vonoprazan. |
| first_indexed | 2024-03-13T03:38:43Z |
| format | Article |
| id | doaj.art-ac1976321b6341f2b3feab136665bb2b |
| institution | Directory Open Access Journal |
| issn | 1756-2848 |
| language | English |
| last_indexed | 2024-03-13T03:38:43Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-ac1976321b6341f2b3feab136665bb2b2023-06-23T11:34:10ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482023-06-011610.1177/17562848231167284Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infectionSteven F. MossWilliam D. CheyPatrick DanieleCorey PelletierRinu JacobGabriel TremblayElizabeth HubscherEckhard LeifkePeter MalfertheinerBackground: Helicobacter pylori eradication rates achieved with clarithromycin-based triple therapies are declining due to antibiotic resistance, but data regarding temporal changes in efficacy with these eradication therapies are scarce. Objective: To evaluate the efficacy of clarithromycin-based triple eradication regimens over time. Design: A comprehensive literature review and time-trend analysis. Data sources and methods: Bibliographies of recently published systematic literature reviews were searched and supplemented with a targeted literature review conducted using Medline and Embase databases and ProQuest from conception to May 2021. Studies reporting H. pylori eradication rates of clarithromycin-based triple therapies were included and temporal trends were estimated using a random-effects model. Results: Eradication rates for triple therapies containing proton pump inhibitors (PPIs), clarithromycin, and amoxicillin showed a significant decline over the past 23 years ( p = 0.0315). However, this decline was not significant when eradication rates achieved with vonoprazan-based triple therapy were included ( p = 0.3910). Conclusion: Vonoprazan-based triple therapy partially mitigated the decline in eradication rates seen with PPI-based triple therapy, likely due to more powerful acid suppression of vonoprazan.https://doi.org/10.1177/17562848231167284 |
| spellingShingle | Steven F. Moss William D. Chey Patrick Daniele Corey Pelletier Rinu Jacob Gabriel Tremblay Elizabeth Hubscher Eckhard Leifke Peter Malfertheiner Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection Therapeutic Advances in Gastroenterology |
| title | Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection |
| title_full | Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection |
| title_fullStr | Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection |
| title_full_unstemmed | Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection |
| title_short | Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection |
| title_sort | brief communication global temporal trends in the efficacy of clarithromycin based regimens for the treatment of infection |
| url | https://doi.org/10.1177/17562848231167284 |
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