Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types

Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types

The histone H3K27 demethylase, UTX/KDM6A, plays a critical role in the early development of vertebrates, and mutations are frequently found in various cancers. Several studies on developmental and cancer biology have focused on preferential transcriptional regulation by UTX independently of its H3K2...

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Bibliographic Details
Main Authors: Wendi Sun, Kian Leong Lee, Lorenz Poellinger, Hisao Masai, Hiroyuki Kato
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Epigenetics
Subjects:
utx
kdm6a
h3k27 demethylase
epigenetics
catalytic activity dependency
gene expression profile
mll
cancer
Online Access:http://dx.doi.org/10.1080/15592294.2023.2222245

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