A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsis
Background: Sepsis is one of the leading causes of death in the United States and the most common cause of death among critically ill patients in non-coronary intensive care units. Previous studies have showed pulse pressure (PP) to be a predictor of fluid responsiveness in patients with sepsis. Add...
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2015-12-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://www.jchimp.net/index.php/jchimp/article/view/29426/pdf_11 |
| _version_ | 1797972326610894848 |
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| author | Hassan Al-khalisy Ivan Nikiforov Manjit Jhajj Namratha Kodali Pramil Cheriyath |
| author_facet | Hassan Al-khalisy Ivan Nikiforov Manjit Jhajj Namratha Kodali Pramil Cheriyath |
| author_sort | Hassan Al-khalisy |
| collection | DOAJ |
| description | Background: Sepsis is one of the leading causes of death in the United States and the most common cause of death among critically ill patients in non-coronary intensive care units. Previous studies have showed pulse pressure (PP) to be a predictor of fluid responsiveness in patients with sepsis. Additionally, previous studies have correlated PP to cardiovascular risk factors and increase in mortality in end-stage renal disease patients. Objectives: To determine the correlation between PP and mortality in patients with sepsis. Methods: A retrospective review was conducted on 5,003 patients admitted with the diagnosis of sepsis using ICD-9 codes during the time period from January 2010 to December 2014 at two community-based hospitals in central Pennsylvania. Results: Our study findings showed significant decrease in the mortality when the PP was greater than 70 mmHg of patients with sepsis (p-value: 0.0003, odds ratio: 0.67, 95% confidence limit: 0.54–0.83). Conclusion: Based on our findings, we suggest that PP could be a valuable clinical tool in the early assessment of patients admitted with sepsis and could be used as a prognostic factor to assess and implement management therapy for the patients with sepsis. |
| first_indexed | 2024-04-11T03:46:44Z |
| format | Article |
| id | doaj.art-ac19c56316c44be6a512f7d0e1611cb7 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T03:46:44Z |
| publishDate | 2015-12-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-ac19c56316c44be6a512f7d0e1611cb72023-01-02T02:44:20ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662015-12-01561410.3402/jchimp.v5.2942629426A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsisHassan Al-khalisy0Ivan Nikiforov1Manjit Jhajj2Namratha Kodali3Pramil Cheriyath4Department of Medicine, Pinnacle Health Hospital, Harrisburg, PA, USADepartment of Medicine, Pinnacle Health Hospital, Harrisburg, PA, USADepartment of Medicine, Pinnacle Health Hospital, Harrisburg, PA, USADepartment of Medicine, Pinnacle Health Hospital, Harrisburg, PA, USADepartment of Medicine, Pinnacle Health Hospital, Harrisburg, PA, USABackground: Sepsis is one of the leading causes of death in the United States and the most common cause of death among critically ill patients in non-coronary intensive care units. Previous studies have showed pulse pressure (PP) to be a predictor of fluid responsiveness in patients with sepsis. Additionally, previous studies have correlated PP to cardiovascular risk factors and increase in mortality in end-stage renal disease patients. Objectives: To determine the correlation between PP and mortality in patients with sepsis. Methods: A retrospective review was conducted on 5,003 patients admitted with the diagnosis of sepsis using ICD-9 codes during the time period from January 2010 to December 2014 at two community-based hospitals in central Pennsylvania. Results: Our study findings showed significant decrease in the mortality when the PP was greater than 70 mmHg of patients with sepsis (p-value: 0.0003, odds ratio: 0.67, 95% confidence limit: 0.54–0.83). Conclusion: Based on our findings, we suggest that PP could be a valuable clinical tool in the early assessment of patients admitted with sepsis and could be used as a prognostic factor to assess and implement management therapy for the patients with sepsis.http://www.jchimp.net/index.php/jchimp/article/view/29426/pdf_11sepsispulse pressureseptic shocksepsis mortalitysepsis therapy |
| spellingShingle | Hassan Al-khalisy Ivan Nikiforov Manjit Jhajj Namratha Kodali Pramil Cheriyath A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsis Journal of Community Hospital Internal Medicine Perspectives sepsis pulse pressure septic shock sepsis mortality sepsis therapy |
| title | A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsis |
| title_full | A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsis |
| title_fullStr | A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsis |
| title_full_unstemmed | A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsis |
| title_short | A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsis |
| title_sort | widened pulse pressure a potential valuable prognostic indicator of mortality in patients with sepsis |
| topic | sepsis pulse pressure septic shock sepsis mortality sepsis therapy |
| url | http://www.jchimp.net/index.php/jchimp/article/view/29426/pdf_11 |
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