FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
The expression patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been described, and some studies have tested the role of this protein in the development and function of specific forebrain circuits by diverse methods and in multiple species. Clinically, mutations...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/42012 |
| _version_ | 1811180555375476736 |
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| author | Ryan J Kast Alexandra L Lanjewar Colton D Smith Pat Levitt |
| author_facet | Ryan J Kast Alexandra L Lanjewar Colton D Smith Pat Levitt |
| author_sort | Ryan J Kast |
| collection | DOAJ |
| description | The expression patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been described, and some studies have tested the role of this protein in the development and function of specific forebrain circuits by diverse methods and in multiple species. Clinically, mutations in FOXP2 are associated with severe developmental speech disturbances, and molecular studies indicate that impairment of Foxp2 may lead to dysregulation of genes involved in forebrain histogenesis. Here, anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were characterized in mice. Additionally, Foxp2 was removed from the developing mouse cortex at different prenatal ages using two Cre-recombinase driver lines. Detailed molecular and circuit analyses were undertaken to identify potential disruptions of development. Surprisingly, the results demonstrate that Foxp2 function is not required for many functions that it has been proposed to regulate, and therefore plays a more limited role in cortical development than previously thought. |
| first_indexed | 2024-04-11T09:05:17Z |
| format | Article |
| id | doaj.art-ac19d9b8943048cb9fdf66d43934f169 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:17Z |
| publishDate | 2019-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ac19d9b8943048cb9fdf66d43934f1692022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2019-05-01810.7554/eLife.42012FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesisRyan J Kast0https://orcid.org/0000-0003-3580-8811Alexandra L Lanjewar1https://orcid.org/0000-0002-2037-0717Colton D Smith2Pat Levitt3https://orcid.org/0000-0002-9717-1695Department of Pediatrics and Program in Developmental Neuroscience and Neurogenetics, The Saban Research Institute, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, United StatesDepartment of Pediatrics and Program in Developmental Neuroscience and Neurogenetics, The Saban Research Institute, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, United StatesDepartment of Pediatrics and Program in Developmental Neuroscience and Neurogenetics, The Saban Research Institute, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, United StatesDepartment of Pediatrics and Program in Developmental Neuroscience and Neurogenetics, The Saban Research Institute, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, United StatesThe expression patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been described, and some studies have tested the role of this protein in the development and function of specific forebrain circuits by diverse methods and in multiple species. Clinically, mutations in FOXP2 are associated with severe developmental speech disturbances, and molecular studies indicate that impairment of Foxp2 may lead to dysregulation of genes involved in forebrain histogenesis. Here, anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were characterized in mice. Additionally, Foxp2 was removed from the developing mouse cortex at different prenatal ages using two Cre-recombinase driver lines. Detailed molecular and circuit analyses were undertaken to identify potential disruptions of development. Surprisingly, the results demonstrate that Foxp2 function is not required for many functions that it has been proposed to regulate, and therefore plays a more limited role in cortical development than previously thought.https://elifesciences.org/articles/42012cortexdevelopmentcell fateaxon guidanceneurogenesis |
| spellingShingle | Ryan J Kast Alexandra L Lanjewar Colton D Smith Pat Levitt FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis eLife cortex development cell fate axon guidance neurogenesis |
| title | FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis |
| title_full | FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis |
| title_fullStr | FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis |
| title_full_unstemmed | FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis |
| title_short | FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis |
| title_sort | foxp2 exhibits projection neuron class specific expression but is not required for multiple aspects of cortical histogenesis |
| topic | cortex development cell fate axon guidance neurogenesis |
| url | https://elifesciences.org/articles/42012 |
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