Novel transcription regulatory sequences and factors of the immune evasion protein ICP47 (US12) of herpes simplex viruses

Novel transcription regulatory sequences and factors of the immune evasion protein ICP47 (US12) of herpes simplex viruses

Abstract Background Herpes simplex virus (HSV) can cause encephalitis. Its infected cell polypeptide 47 (ICP47), encoded by immediate-early gene US12, promotes immune escape. ICP47 was modified in the clinically approved oncolytic HSV (oHSV) T-Vec. However, transcription regulatory sequence (TRS) an...

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Bibliographic Details
Main Authors: Jun-Ting Cheng, Ying-Ying Wang, Lin-Zhong Zhu, Ying Zhang, Wen-Qi Cai, Zi-Wen Han, Yang Zhou, Xian-Wang Wang, Xiao-Chun Peng, Ying Xiang, Hui-Yu Yang, Shu-Zhong Cui, Zhaowu Ma, Bing-Rong Liu, Hong-Wu Xin
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Virology Journal
Subjects:
HSV-1
HSV-2
US12
ICP47
Transcriptional regulation sequence (TRS)
Transcriptional regulation factor (TRF)
Online Access:http://link.springer.com/article/10.1186/s12985-020-01365-3

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