The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis
Pengcheng Jiao,1,* Zuntai Li,2,* Birong Li,3 Xingyuan Jiao4 1Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Hospital of Stomatology, Jilin University, Changchun, Jilin, People’s Republic of China; 3Changzhou Hospital of Trad...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/the-role-of-caspase-11-and-pyroptosis-in-the-regulation-of-inflammatio-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797658990210973696 |
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| author | Jiao P Li Z Li B Jiao X |
| author_facet | Jiao P Li Z Li B Jiao X |
| author_sort | Jiao P |
| collection | DOAJ |
| description | Pengcheng Jiao,1,* Zuntai Li,2,* Birong Li,3 Xingyuan Jiao4 1Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Hospital of Stomatology, Jilin University, Changchun, Jilin, People’s Republic of China; 3Changzhou Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, People’s Republic of China; 4Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xingyuan Jiao, Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510000, People’s Republic of China, Tel +86-13178813750, Email jiaoxingyuan@hotmail.comAbstract: Peri-implantitis is an important cause of oral implant failure. In the past, TLR4 and TLR2 in the Toll-like family were generally considered as the key immune recognition receptors regulating peri-implantitis. However, under the guidance of this theory, there are still some unexplainable peri-implantitis symptoms. With the discovery of novel intracellular LPS receptor Caspase-11, a new understanding of inflammatory signaling and immune regulation in the development of peri-implantitis has been gained. However, the regulatory role of Caspase-11 in peri-implantitis and its crosstalk with the TLR4 pathway remain unclear. The therapeutic effect of drugs targeting Caspase-11 on peri-implantitis is still in its early stages. In view of this situation, this paper reviews the possible role of Caspase-11 in peri-implant inflammation, elaborated the entry process of LPS and the activation mechanism of Caspase-11, and analyzes the differences in Caspase-11 between commonly studied animals, mice and humans. The current research hotspots and challenges are also analyzed to provide new insights and ideas for researchers.Keywords: caspase-11, pyroptosis, inflammation, peri-implantitis |
| first_indexed | 2024-03-11T18:07:32Z |
| format | Article |
| id | doaj.art-ac1b6cff95ef49588f72f8c3ef21f165 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-11T18:07:32Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-ac1b6cff95ef49588f72f8c3ef21f1652023-10-17T02:44:42ZengDove Medical PressJournal of Inflammation Research1178-70312023-10-01Volume 164471447987280The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-ImplantitisJiao PLi ZLi BJiao XPengcheng Jiao,1,* Zuntai Li,2,* Birong Li,3 Xingyuan Jiao4 1Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Hospital of Stomatology, Jilin University, Changchun, Jilin, People’s Republic of China; 3Changzhou Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, People’s Republic of China; 4Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xingyuan Jiao, Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510000, People’s Republic of China, Tel +86-13178813750, Email jiaoxingyuan@hotmail.comAbstract: Peri-implantitis is an important cause of oral implant failure. In the past, TLR4 and TLR2 in the Toll-like family were generally considered as the key immune recognition receptors regulating peri-implantitis. However, under the guidance of this theory, there are still some unexplainable peri-implantitis symptoms. With the discovery of novel intracellular LPS receptor Caspase-11, a new understanding of inflammatory signaling and immune regulation in the development of peri-implantitis has been gained. However, the regulatory role of Caspase-11 in peri-implantitis and its crosstalk with the TLR4 pathway remain unclear. The therapeutic effect of drugs targeting Caspase-11 on peri-implantitis is still in its early stages. In view of this situation, this paper reviews the possible role of Caspase-11 in peri-implant inflammation, elaborated the entry process of LPS and the activation mechanism of Caspase-11, and analyzes the differences in Caspase-11 between commonly studied animals, mice and humans. The current research hotspots and challenges are also analyzed to provide new insights and ideas for researchers.Keywords: caspase-11, pyroptosis, inflammation, peri-implantitishttps://www.dovepress.com/the-role-of-caspase-11-and-pyroptosis-in-the-regulation-of-inflammatio-peer-reviewed-fulltext-article-JIRcaspase-11pyroptosisinflammationperi-implantitis |
| spellingShingle | Jiao P Li Z Li B Jiao X The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis Journal of Inflammation Research caspase-11 pyroptosis inflammation peri-implantitis |
| title | The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis |
| title_full | The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis |
| title_fullStr | The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis |
| title_full_unstemmed | The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis |
| title_short | The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis |
| title_sort | role of caspase 11 and pyroptosis in the regulation of inflammation in peri implantitis |
| topic | caspase-11 pyroptosis inflammation peri-implantitis |
| url | https://www.dovepress.com/the-role-of-caspase-11-and-pyroptosis-in-the-regulation-of-inflammatio-peer-reviewed-fulltext-article-JIR |
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