Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study
Mechanisms related to the potential beneficial effects of statins on cancer are mainly related to the inhibition of the mevalonate pathway. The purpose of this study was to assess the association between prior use of statins and the risk of head and neck cancer. A hospital-based case–control study w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/5/579 |
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| author | Constanza Saka-Herrán Enric Jané-Salas Antonio Mano-Azul Aina Torrejón-Moya Albert Estrugo-Devesa José López-López |
| author_facet | Constanza Saka-Herrán Enric Jané-Salas Antonio Mano-Azul Aina Torrejón-Moya Albert Estrugo-Devesa José López-López |
| author_sort | Constanza Saka-Herrán |
| collection | DOAJ |
| description | Mechanisms related to the potential beneficial effects of statins on cancer are mainly related to the inhibition of the mevalonate pathway. The purpose of this study was to assess the association between prior use of statins and the risk of head and neck cancer. A hospital-based case–control study was conducted at the Dentistry Hospital of the University of Barcelona, including 101 incident cases of head and neck cancer and 101 controls matched to cases by age and sex. Multivariate logistic regression models were used to assess the association between prior statin exposure and head and neck cancer risk. Of the 202 patients included in total, 28.2% had previously received prescriptions for statins. Prior use of statins was found in 25.7% of cases and 30.7% of controls. Exposure to statins was not associated with head and neck cancer risk (OR = 0.72; 95% CI 0.28–1.84; <i>p</i> = 0.49). There was also no time- or dose-dependent association. Similar trends were observed when analyzed by subsites of cancer and recurrence rate. Our findings do not support a beneficial effect of prior statin exposure on head and neck cancer risk. Future research relying on observational data should emulate randomized clinical trials before clinical implications for repurposing drugs can be drawn. |
| first_indexed | 2024-03-10T03:09:45Z |
| format | Article |
| id | doaj.art-ac1d8804ab344237bff36edb0522f455 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:09:45Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ac1d8804ab344237bff36edb0522f4552023-11-23T12:34:51ZengMDPI AGPharmaceuticals1424-82472022-05-0115557910.3390/ph15050579Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control StudyConstanza Saka-Herrán0Enric Jané-Salas1Antonio Mano-Azul2Aina Torrejón-Moya3Albert Estrugo-Devesa4José López-López5Department of Odontostomatology, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, 08970 Barcelona, SpainDepartment of Odontostomatology, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, 08970 Barcelona, SpainDepartment of Oral Surgery, Oral Medicine, and Maxillofacial Surgery, Egas Moniz Higher Education School, Campus Universitario, Quinta da Granja, 2829-511 Caparica, PortugalDepartment of Odontostomatology, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, 08970 Barcelona, SpainDepartment of Odontostomatology, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, 08970 Barcelona, SpainDepartment of Odontostomatology, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, 08970 Barcelona, SpainMechanisms related to the potential beneficial effects of statins on cancer are mainly related to the inhibition of the mevalonate pathway. The purpose of this study was to assess the association between prior use of statins and the risk of head and neck cancer. A hospital-based case–control study was conducted at the Dentistry Hospital of the University of Barcelona, including 101 incident cases of head and neck cancer and 101 controls matched to cases by age and sex. Multivariate logistic regression models were used to assess the association between prior statin exposure and head and neck cancer risk. Of the 202 patients included in total, 28.2% had previously received prescriptions for statins. Prior use of statins was found in 25.7% of cases and 30.7% of controls. Exposure to statins was not associated with head and neck cancer risk (OR = 0.72; 95% CI 0.28–1.84; <i>p</i> = 0.49). There was also no time- or dose-dependent association. Similar trends were observed when analyzed by subsites of cancer and recurrence rate. Our findings do not support a beneficial effect of prior statin exposure on head and neck cancer risk. Future research relying on observational data should emulate randomized clinical trials before clinical implications for repurposing drugs can be drawn.https://www.mdpi.com/1424-8247/15/5/579statinshydroxymethilglutaryl-CoA reductase inhibitorshead and neck cancerhead and neck neoplasmscancerrisk |
| spellingShingle | Constanza Saka-Herrán Enric Jané-Salas Antonio Mano-Azul Aina Torrejón-Moya Albert Estrugo-Devesa José López-López Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study Pharmaceuticals statins hydroxymethilglutaryl-CoA reductase inhibitors head and neck cancer head and neck neoplasms cancer risk |
| title | Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study |
| title_full | Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study |
| title_fullStr | Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study |
| title_full_unstemmed | Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study |
| title_short | Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study |
| title_sort | effects of the prior use of statins on head and neck cancer risk a hospital based case control study |
| topic | statins hydroxymethilglutaryl-CoA reductase inhibitors head and neck cancer head and neck neoplasms cancer risk |
| url | https://www.mdpi.com/1424-8247/15/5/579 |
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