Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

<p>Abstract</p> <p>Background</p> <p>Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side-effe...

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Bibliographic Details
Main Authors: Kilic Ulkan, Kilic Ertugrul, Tuzcu Zeynep, Tuzcu Mehmet, Ozercan Ibrahim H, Yilmaz Okkes, Sahin Fikrettin, Sahin Kazim
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Nutrition & Metabolism
Subjects:
Nephrotoxicity
Nrf2/HO-1 signaling
Melatonin
Oxidative stress
Online Access:http://www.nutritionandmetabolism.com/content/10/1/7

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