Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review
Mycobacteria are intracellular bacterial parasites which survive and proliferate inside of macrophages for long periods of time. Because mycobacterial survival in macrophages is required for virulence, a great deal of effort has been focused on identifying the genetic and physiologic determinants of...
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Format: | Article |
Language: | English |
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Czech Academy of Agricultural Sciences
2004-05-01
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Series: | Veterinární Medicína |
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Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-200405-0003_mycobacterial-catalases-peroxidases-and-superoxide-dismutases-and-their-effects-on-virulence-and-isoniazid-su.php |
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author | M. Bartos J. O. Falkinham III I. Pavlik |
author_facet | M. Bartos J. O. Falkinham III I. Pavlik |
author_sort | M. Bartos |
collection | DOAJ |
description | Mycobacteria are intracellular bacterial parasites which survive and proliferate inside of macrophages for long periods of time. Because mycobacterial survival in macrophages is required for virulence, a great deal of effort has been focused on identifying the genetic and physiologic determinants of intracellular survival and growth. A number of factors, among them catalases, peroxidases, and superoxide dismutase have been suggested as agents permitting mycobacteria to overcome the intracellular defences of macrophages. The characteristic features of mycobacterial catalase/peroxidases and superoxide dismutase, their distribution within the genus Mycobacterium, and their mutual interactions in the inactivation of toxic oxygen products are reviewed. Focus is placed on evidence of the role of mycobacterial catalase-peroxidase and superoxide dismutase in virulence and on the role of catalase-peroxidase in susceptibility to isonicotinic acid hydrazide. |
first_indexed | 2024-04-10T08:03:13Z |
format | Article |
id | doaj.art-ac1eda0d94084ccfbf7c8616254a628a |
institution | Directory Open Access Journal |
issn | 0375-8427 1805-9392 |
language | English |
last_indexed | 2024-04-10T08:03:13Z |
publishDate | 2004-05-01 |
publisher | Czech Academy of Agricultural Sciences |
record_format | Article |
series | Veterinární Medicína |
spelling | doaj.art-ac1eda0d94084ccfbf7c8616254a628a2023-02-23T03:49:09ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922004-05-0149516117010.17221/5691-VETMEDvet-200405-0003Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a reviewM. Bartos0J. O. Falkinham III1I. Pavlik2Veterinary Research Institute, Brno, Czech RepublicVeterinary Research Institute, Brno, Czech RepublicVeterinary Research Institute, Brno, Czech RepublicMycobacteria are intracellular bacterial parasites which survive and proliferate inside of macrophages for long periods of time. Because mycobacterial survival in macrophages is required for virulence, a great deal of effort has been focused on identifying the genetic and physiologic determinants of intracellular survival and growth. A number of factors, among them catalases, peroxidases, and superoxide dismutase have been suggested as agents permitting mycobacteria to overcome the intracellular defences of macrophages. The characteristic features of mycobacterial catalase/peroxidases and superoxide dismutase, their distribution within the genus Mycobacterium, and their mutual interactions in the inactivation of toxic oxygen products are reviewed. Focus is placed on evidence of the role of mycobacterial catalase-peroxidase and superoxide dismutase in virulence and on the role of catalase-peroxidase in susceptibility to isonicotinic acid hydrazide.https://vetmed.agriculturejournals.cz/artkey/vet-200405-0003_mycobacterial-catalases-peroxidases-and-superoxide-dismutases-and-their-effects-on-virulence-and-isoniazid-su.phptuberculosisantituberculotic drugsmycobacterium tuberculosismycobacterium aviumtherapy |
spellingShingle | M. Bartos J. O. Falkinham III I. Pavlik Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review Veterinární Medicína tuberculosis antituberculotic drugs mycobacterium tuberculosis mycobacterium avium therapy |
title | Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review |
title_full | Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review |
title_fullStr | Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review |
title_full_unstemmed | Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review |
title_short | Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review |
title_sort | mycobacterial catalases peroxidases and superoxide dismutases and their effects on virulence and isoniazid susceptibility in mycobacteria a review |
topic | tuberculosis antituberculotic drugs mycobacterium tuberculosis mycobacterium avium therapy |
url | https://vetmed.agriculturejournals.cz/artkey/vet-200405-0003_mycobacterial-catalases-peroxidases-and-superoxide-dismutases-and-their-effects-on-virulence-and-isoniazid-su.php |
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