The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches
Cardiovascular diseases (CVDs) are closely linked to cellular oxidative stress and inflammation. This may be resulted from the imbalance generation of reactive oxygen species and its role in promoting inflammation, thereby contributing to endothelial dysfunction and cardiovascular complications. Nuc...
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| Format: | Article |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01308/full |
| _version_ | 1818266051921575936 |
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| author | Bee Kee Ooi Kok-Gan Chan Kok-Gan Chan Bey Hing Goh Bey Hing Goh Bey Hing Goh Bey Hing Goh Wei Hsum Yap |
| author_facet | Bee Kee Ooi Kok-Gan Chan Kok-Gan Chan Bey Hing Goh Bey Hing Goh Bey Hing Goh Bey Hing Goh Wei Hsum Yap |
| author_sort | Bee Kee Ooi |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are closely linked to cellular oxidative stress and inflammation. This may be resulted from the imbalance generation of reactive oxygen species and its role in promoting inflammation, thereby contributing to endothelial dysfunction and cardiovascular complications. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that plays a significant role in regulating expression of antioxidant and cytoprotective enzymes in response to oxidative stress. Natural products have emerged as a potential source of bioactive compounds which have shown to protect against atherogenesis development by activating Nrf2 signaling. This review aims to provide a comprehensive summary of the published data on the function, regulation and activation of Nrf2 as well as the molecular mechanisms of natural products in regulating Nrf2 signaling. The beneficial effects of using natural bioactive compounds as a promising therapeutic approach for the prevention and treatment of CVDs are reviewed. |
| first_indexed | 2024-12-12T20:00:34Z |
| format | Article |
| id | doaj.art-ac1f760b563742618644fb30aff716b1 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T20:00:34Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-ac1f760b563742618644fb30aff716b12022-12-22T00:13:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-11-01910.3389/fphar.2018.01308420395The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic ApproachesBee Kee Ooi0Kok-Gan Chan1Kok-Gan Chan2Bey Hing Goh3Bey Hing Goh4Bey Hing Goh5Bey Hing Goh6Wei Hsum Yap7School of Biosciences, Taylor’s University, Subang Jaya, MalaysiaDivision of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, MalaysiaInternational Genome Centre, Jiangsu University, Zhenjiang, ChinaBiofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, MalaysiaNovel Bacteria and Drug Discovery Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, MalaysiaAsian Centre for Evidence Synthesis in Population, Implementation and Clinical Outcomes, Health and Well-Being Cluster, Global Asia in the 21st Century Platform, Monash University Malaysia, Bandar Sunway, MalaysiaCenter of Health Outcomes Research and Therapeutic Safety, School of Pharmaceutical Sciences, University of Phayao, Phayao, ThailandSchool of Biosciences, Taylor’s University, Subang Jaya, MalaysiaCardiovascular diseases (CVDs) are closely linked to cellular oxidative stress and inflammation. This may be resulted from the imbalance generation of reactive oxygen species and its role in promoting inflammation, thereby contributing to endothelial dysfunction and cardiovascular complications. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that plays a significant role in regulating expression of antioxidant and cytoprotective enzymes in response to oxidative stress. Natural products have emerged as a potential source of bioactive compounds which have shown to protect against atherogenesis development by activating Nrf2 signaling. This review aims to provide a comprehensive summary of the published data on the function, regulation and activation of Nrf2 as well as the molecular mechanisms of natural products in regulating Nrf2 signaling. The beneficial effects of using natural bioactive compounds as a promising therapeutic approach for the prevention and treatment of CVDs are reviewed.https://www.frontiersin.org/article/10.3389/fphar.2018.01308/fullnuclear factor erythroid 2-related factor 2 (Nrf2)cardiovascular diseases (CVDs)natural productsoxidative stressnuclear factor-κB (NF-κB) |
| spellingShingle | Bee Kee Ooi Kok-Gan Chan Kok-Gan Chan Bey Hing Goh Bey Hing Goh Bey Hing Goh Bey Hing Goh Wei Hsum Yap The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches Frontiers in Pharmacology nuclear factor erythroid 2-related factor 2 (Nrf2) cardiovascular diseases (CVDs) natural products oxidative stress nuclear factor-κB (NF-κB) |
| title | The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches |
| title_full | The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches |
| title_fullStr | The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches |
| title_full_unstemmed | The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches |
| title_short | The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches |
| title_sort | role of natural products in targeting cardiovascular diseases via nrf2 pathway novel molecular mechanisms and therapeutic approaches |
| topic | nuclear factor erythroid 2-related factor 2 (Nrf2) cardiovascular diseases (CVDs) natural products oxidative stress nuclear factor-κB (NF-κB) |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01308/full |
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