A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge
The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection.
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04758-9 |
| _version_ | 1818841482927276032 |
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| author | Navid Madani Amy M. Princiotto Linh Mach Shilei Ding Jérémie Prevost Jonathan Richard Bhavna Hora Laura Sutherland Connie A. Zhao Brandon P. Conn Todd Bradley M. Anthony Moody Bruno Melillo Andrés Finzi Barton F. Haynes Amos B. Smith III Sampa Santra Joseph Sodroski |
| author_facet | Navid Madani Amy M. Princiotto Linh Mach Shilei Ding Jérémie Prevost Jonathan Richard Bhavna Hora Laura Sutherland Connie A. Zhao Brandon P. Conn Todd Bradley M. Anthony Moody Bruno Melillo Andrés Finzi Barton F. Haynes Amos B. Smith III Sampa Santra Joseph Sodroski |
| author_sort | Navid Madani |
| collection | DOAJ |
| description | The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection. |
| first_indexed | 2024-12-19T04:26:47Z |
| format | Article |
| id | doaj.art-ac213354426e4f05910a41474b6a0b00 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:26:47Z |
| publishDate | 2018-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ac213354426e4f05910a41474b6a0b002022-12-21T20:36:00ZengNature PortfolioNature Communications2041-17232018-06-01911910.1038/s41467-018-04758-9A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challengeNavid Madani0Amy M. Princiotto1Linh Mach2Shilei Ding3Jérémie Prevost4Jonathan Richard5Bhavna Hora6Laura Sutherland7Connie A. Zhao8Brandon P. Conn9Todd Bradley10M. Anthony Moody11Bruno Melillo12Andrés Finzi13Barton F. Haynes14Amos B. Smith III15Sampa Santra16Joseph Sodroski17Department of Cancer Immunology and Virology, Dana-Farber Cancer InstituteDepartment of Cancer Immunology and Virology, Dana-Farber Cancer InstituteCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCentre de Recherche du CHUMCentre de Recherche du CHUMCentre de Recherche du CHUMDepartment of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical CenterDepartment of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical CenterDepartment of Cancer Immunology and Virology, Dana-Farber Cancer InstituteCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical CenterDepartment of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical CenterDepartment of Chemistry, University of PennsylvaniaCentre de Recherche du CHUMDepartment of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical CenterDepartment of Chemistry, University of PennsylvaniaCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Cancer Immunology and Virology, Dana-Farber Cancer InstituteThe HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection.https://doi.org/10.1038/s41467-018-04758-9 |
| spellingShingle | Navid Madani Amy M. Princiotto Linh Mach Shilei Ding Jérémie Prevost Jonathan Richard Bhavna Hora Laura Sutherland Connie A. Zhao Brandon P. Conn Todd Bradley M. Anthony Moody Bruno Melillo Andrés Finzi Barton F. Haynes Amos B. Smith III Sampa Santra Joseph Sodroski A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge Nature Communications |
| title | A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_full | A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_fullStr | A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_full_unstemmed | A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_short | A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_sort | cd4 mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| url | https://doi.org/10.1038/s41467-018-04758-9 |
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