Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients
Background: Diabetes mellitus (DM) is a group of metabolic disorders Characterized by chronic hyperglycaemic condition resulting from defects in insulin secretion, insulin action or both. Type2 Diabetes Mellitus (T2DM) is the predominant form of diabetes and represent 90% of all cases of DM. Studies...
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| Format: | Article |
| Language: | English |
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Ain Shams University
2021-07-01
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| Series: | Archives of Pharmaceutical Sciences Ain Shams University |
| Subjects: | |
| Online Access: | https://aps.journals.ekb.eg/article_176769.html |
| _version_ | 1819225312965165056 |
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| author | Yasmin Elnaggar Mai Tolba Mohamed Halawa Ebtehal El-Demerdash |
| author_facet | Yasmin Elnaggar Mai Tolba Mohamed Halawa Ebtehal El-Demerdash |
| author_sort | Yasmin Elnaggar |
| collection | DOAJ |
| description | Background: Diabetes mellitus (DM) is a group of metabolic disorders Characterized by chronic hyperglycaemic condition resulting from defects in insulin secretion, insulin action or both. Type2 Diabetes Mellitus (T2DM) is the predominant form of diabetes and represent 90% of all cases of DM. Studies show that vitamin D (VD) has an important role in modifying the risk of T2DM, especially among insulin resistant diabetic patients. Recently a novel association between insulin resistance and vitamin D deficiency has been proposed. Aim: In the current research we investigate the association between hypovitaminosis D and T2DM. Also we will study the effect of vitamin D supplementation on glycemic status, oxidative stress status and inflammatory markers in T2DM patients. Methods and patients: forty T2DM patients with hypovitaminosis D were assessed for glycemic, inflammatory and antioxidants parameters. After 6 months of VD supplementation for the intervention group of patients (n=20), there was significant improvement in VD level, Homeostatic model assessment of insulin resistance (HOMA - IR), Fasting blood glucose (FBG), glycated haemoglobin (HbAIC), serum insulin, interleukin 6 (IL-6), tumor necrosis factor -α (TNF-α), total antioxidant capacity (TAC) and malondialdehyde (MDA). Conclusion: Vitamin D supplementation has a promising effect on the treatment of Type 2 Diabetes as there is a significant improvement in glycemic , inflammatory and oxidative parameters in Type 2 Diabetes mellitus patients |
| first_indexed | 2024-12-23T10:07:36Z |
| format | Article |
| id | doaj.art-ac2244e340ee448cacb2045a0afc45cd |
| institution | Directory Open Access Journal |
| issn | 2356-8380 2356-8399 |
| language | English |
| last_indexed | 2024-12-23T10:07:36Z |
| publishDate | 2021-07-01 |
| publisher | Ain Shams University |
| record_format | Article |
| series | Archives of Pharmaceutical Sciences Ain Shams University |
| spelling | doaj.art-ac2244e340ee448cacb2045a0afc45cd2022-12-21T17:51:03ZengAin Shams UniversityArchives of Pharmaceutical Sciences Ain Shams University2356-83802356-83992021-07-0151115https://dx.doi.org/10.21608/aps.2021.58439.1051Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus PatientsYasmin Elnaggar0Mai Tolba1Mohamed Halawa2Ebtehal El-Demerdash3Clinical pharmacy, Ain Shams University Specialised Hospital, Cairo 11588, EgyptPharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, EgyptEndocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptBackground: Diabetes mellitus (DM) is a group of metabolic disorders Characterized by chronic hyperglycaemic condition resulting from defects in insulin secretion, insulin action or both. Type2 Diabetes Mellitus (T2DM) is the predominant form of diabetes and represent 90% of all cases of DM. Studies show that vitamin D (VD) has an important role in modifying the risk of T2DM, especially among insulin resistant diabetic patients. Recently a novel association between insulin resistance and vitamin D deficiency has been proposed. Aim: In the current research we investigate the association between hypovitaminosis D and T2DM. Also we will study the effect of vitamin D supplementation on glycemic status, oxidative stress status and inflammatory markers in T2DM patients. Methods and patients: forty T2DM patients with hypovitaminosis D were assessed for glycemic, inflammatory and antioxidants parameters. After 6 months of VD supplementation for the intervention group of patients (n=20), there was significant improvement in VD level, Homeostatic model assessment of insulin resistance (HOMA - IR), Fasting blood glucose (FBG), glycated haemoglobin (HbAIC), serum insulin, interleukin 6 (IL-6), tumor necrosis factor -α (TNF-α), total antioxidant capacity (TAC) and malondialdehyde (MDA). Conclusion: Vitamin D supplementation has a promising effect on the treatment of Type 2 Diabetes as there is a significant improvement in glycemic , inflammatory and oxidative parameters in Type 2 Diabetes mellitus patientshttps://aps.journals.ekb.eg/article_176769.htmltype 2 diabetes mellituscytokinesoxidative stressvitamin dinsulin resistance |
| spellingShingle | Yasmin Elnaggar Mai Tolba Mohamed Halawa Ebtehal El-Demerdash Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients Archives of Pharmaceutical Sciences Ain Shams University type 2 diabetes mellitus cytokines oxidative stress vitamin d insulin resistance |
| title | Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients |
| title_full | Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients |
| title_fullStr | Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients |
| title_full_unstemmed | Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients |
| title_short | Investigation of the Clinical Outcomes of Long-Term Vitamin D Supplementation in Egyptian Type 2 Diabetes Mellitus Patients |
| title_sort | investigation of the clinical outcomes of long term vitamin d supplementation in egyptian type 2 diabetes mellitus patients |
| topic | type 2 diabetes mellitus cytokines oxidative stress vitamin d insulin resistance |
| url | https://aps.journals.ekb.eg/article_176769.html |
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