Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections
Updated vaccines based on Omicron subvariants have started to being rolled out. Analysis of antibody response in individuals with two or three vaccine doses suggests that BA.2 breakthrough infection barely increases cross-neutralization capacity against BA.4/5 or BA.2.75.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34400-8 |
| _version_ | 1828286858283450368 |
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| author | Bin Ju Qing Fan Miao Wang Xuejiao Liao Huimin Guo Haiyan Wang Xiangyang Ge Lei Liu Zheng Zhang |
| author_facet | Bin Ju Qing Fan Miao Wang Xuejiao Liao Huimin Guo Haiyan Wang Xiangyang Ge Lei Liu Zheng Zhang |
| author_sort | Bin Ju |
| collection | DOAJ |
| description | Updated vaccines based on Omicron subvariants have started to being rolled out. Analysis of antibody response in individuals with two or three vaccine doses suggests that BA.2 breakthrough infection barely increases cross-neutralization capacity against BA.4/5 or BA.2.75. |
| first_indexed | 2024-04-13T09:39:08Z |
| format | Article |
| id | doaj.art-ac22485f396246829edeef99d34e164b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T09:39:08Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ac22485f396246829edeef99d34e164b2022-12-22T02:52:01ZengNature PortfolioNature Communications2041-17232022-11-011311610.1038/s41467-022-34400-8Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infectionsBin Ju0Qing Fan1Miao Wang2Xuejiao Liao3Huimin Guo4Haiyan Wang5Xiangyang Ge6Lei Liu7Zheng Zhang8Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s HospitalUpdated vaccines based on Omicron subvariants have started to being rolled out. Analysis of antibody response in individuals with two or three vaccine doses suggests that BA.2 breakthrough infection barely increases cross-neutralization capacity against BA.4/5 or BA.2.75.https://doi.org/10.1038/s41467-022-34400-8 |
| spellingShingle | Bin Ju Qing Fan Miao Wang Xuejiao Liao Huimin Guo Haiyan Wang Xiangyang Ge Lei Liu Zheng Zhang Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections Nature Communications |
| title | Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections |
| title_full | Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections |
| title_fullStr | Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections |
| title_full_unstemmed | Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections |
| title_short | Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections |
| title_sort | antigenic sin of wild type sars cov 2 vaccine shapes poor cross neutralization of ba 4 5 2 75 subvariants in ba 2 breakthrough infections |
| url | https://doi.org/10.1038/s41467-022-34400-8 |
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