Membranous nephropathy: the current state of the problem
Membranous nephropathy (MN) is an autoimmune disease of the kidney glomeruli and one of the leading causes of nephrotic syndrome. The disease exhibits heterogenous outcomes with approximately 30 % of cases progressing to end-stage renal disease. The study of MN pathogenesis has steadily advanced owi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2023-06-01
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| Series: | Počki |
| Subjects: | |
| Online Access: | https://kidneys.zaslavsky.com.ua/index.php/journal/article/view/406 |
| _version_ | 1797672312630149120 |
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| author | O.N. Sharapov Sh.S. Abdullaev |
| author_facet | O.N. Sharapov Sh.S. Abdullaev |
| author_sort | O.N. Sharapov |
| collection | DOAJ |
| description | Membranous nephropathy (MN) is an autoimmune disease of the kidney glomeruli and one of the leading causes of nephrotic syndrome. The disease exhibits heterogenous outcomes with approximately 30 % of cases progressing to end-stage renal disease. The study of MN pathogenesis has steadily advanced owing to the identification of autoantibodies to the phospholipase A2 receptor (PLA2R) in 2009 and thrombospondin domain-containing 7A (THSD7A) on the podocyte surface in 2014. Approximately 50–80 and 3–5 % of primary MN cases are associated with either anti-PLA2R or anti-THSD7A antibodies, respectively. The presence of these autoantibodies is used for MN diagnosis; antibody levels correlate with disease severity and possess significant biomarker values in monitoring disease progression and treatment response. |
| first_indexed | 2024-03-11T21:28:08Z |
| format | Article |
| id | doaj.art-ac238fcf0cf745ddb3d79466bbb55040 |
| institution | Directory Open Access Journal |
| issn | 2307-1257 2307-1265 |
| language | English |
| last_indexed | 2024-03-11T21:28:08Z |
| publishDate | 2023-06-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Počki |
| spelling | doaj.art-ac238fcf0cf745ddb3d79466bbb550402023-09-27T17:47:28ZengZaslavsky O.Yu.Počki2307-12572307-12652023-06-0112211111810.22141/2307-1257.12.2.2023.406406Membranous nephropathy: the current state of the problemO.N. Sharapov0Sh.S. Abdullaev1Republican Specialized Scientific Practical Medical Center of Nephrology and Kidney Transplantation, Tashkent, Uzbekistan; Tashkent Pediatric Medical Institute, Tashkent, UzbekistanRepublican Specialized Scientific Practical Medical Center of Nephrology and Kidney Transplantation, Tashkent, Uzbekistan; Tashkent Pediatric Medical Institute, Tashkent, UzbekistanMembranous nephropathy (MN) is an autoimmune disease of the kidney glomeruli and one of the leading causes of nephrotic syndrome. The disease exhibits heterogenous outcomes with approximately 30 % of cases progressing to end-stage renal disease. The study of MN pathogenesis has steadily advanced owing to the identification of autoantibodies to the phospholipase A2 receptor (PLA2R) in 2009 and thrombospondin domain-containing 7A (THSD7A) on the podocyte surface in 2014. Approximately 50–80 and 3–5 % of primary MN cases are associated with either anti-PLA2R or anti-THSD7A antibodies, respectively. The presence of these autoantibodies is used for MN diagnosis; antibody levels correlate with disease severity and possess significant biomarker values in monitoring disease progression and treatment response.https://kidneys.zaslavsky.com.ua/index.php/journal/article/view/406membranous nephropathynephrotic syndromebasement membrane of the glomerulusproteinuriaantibodiespla2rthsd7areview |
| spellingShingle | O.N. Sharapov Sh.S. Abdullaev Membranous nephropathy: the current state of the problem Počki membranous nephropathy nephrotic syndrome basement membrane of the glomerulus proteinuria antibodies pla2r thsd7a review |
| title | Membranous nephropathy: the current state of the problem |
| title_full | Membranous nephropathy: the current state of the problem |
| title_fullStr | Membranous nephropathy: the current state of the problem |
| title_full_unstemmed | Membranous nephropathy: the current state of the problem |
| title_short | Membranous nephropathy: the current state of the problem |
| title_sort | membranous nephropathy the current state of the problem |
| topic | membranous nephropathy nephrotic syndrome basement membrane of the glomerulus proteinuria antibodies pla2r thsd7a review |
| url | https://kidneys.zaslavsky.com.ua/index.php/journal/article/view/406 |
| work_keys_str_mv | AT onsharapov membranousnephropathythecurrentstateoftheproblem AT shsabdullaev membranousnephropathythecurrentstateoftheproblem |