Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation
Michael D Keller, Catherine M Bollard Program for Cell Enhancement and Technologies for Immunotherapy, Sheikh Zayed Institute for Pediatric Surgical Innovation, and Center for Cancer and Immunology Research, Children’s National Health System, Washington, DC, USA Abstract: Anti-pathogen ad...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014-06-01
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| Series: | ImmunoTargets and Therapy |
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| Online Access: | https://www.dovepress.com/immunologic-special-forces-anti-pathogen-cytotoxic-t-lymphocyte-immuno-peer-reviewed-article-ITT |
| _version_ | 1818260144545333248 |
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| author | Keller MD Bollard CM |
| author_facet | Keller MD Bollard CM |
| author_sort | Keller MD |
| collection | DOAJ |
| description | Michael D Keller, Catherine M Bollard Program for Cell Enhancement and Technologies for Immunotherapy, Sheikh Zayed Institute for Pediatric Surgical Innovation, and Center for Cancer and Immunology Research, Children’s National Health System, Washington, DC, USA Abstract: Anti-pathogen adoptive T-cell immunotherapy has been proven to be highly effective in preventing or controlling viral infections following hematopoietic stem cell transplantation. Recent advances in manufacturing protocols allow an increased number of targeted pathogens, eliminate the need for viral transduction, broaden the potential donor pool to include pathogen-naïve sources, and reduce the time requirement for production. Early studies suggest that anti-fungal immunotherapy may also have clinical benefit. Future advances include further broadening of the pathogens that can be targeted and development of T-cells with resistance to pharmacologic immunosuppression. Keywords: immunotherapy, stem cell transplantation, T-cell, virus, fungus |
| first_indexed | 2024-12-12T18:26:40Z |
| format | Article |
| id | doaj.art-ac23cfaff98449b080cd55176e443db8 |
| institution | Directory Open Access Journal |
| issn | 2253-1556 |
| language | English |
| last_indexed | 2024-12-12T18:26:40Z |
| publishDate | 2014-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | ImmunoTargets and Therapy |
| spelling | doaj.art-ac23cfaff98449b080cd55176e443db82022-12-22T00:16:01ZengDove Medical PressImmunoTargets and Therapy2253-15562014-06-012014Issue 19710617258Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantationKeller MDBollard CMMichael D Keller, Catherine M Bollard Program for Cell Enhancement and Technologies for Immunotherapy, Sheikh Zayed Institute for Pediatric Surgical Innovation, and Center for Cancer and Immunology Research, Children’s National Health System, Washington, DC, USA Abstract: Anti-pathogen adoptive T-cell immunotherapy has been proven to be highly effective in preventing or controlling viral infections following hematopoietic stem cell transplantation. Recent advances in manufacturing protocols allow an increased number of targeted pathogens, eliminate the need for viral transduction, broaden the potential donor pool to include pathogen-naïve sources, and reduce the time requirement for production. Early studies suggest that anti-fungal immunotherapy may also have clinical benefit. Future advances include further broadening of the pathogens that can be targeted and development of T-cells with resistance to pharmacologic immunosuppression. Keywords: immunotherapy, stem cell transplantation, T-cell, virus, fungushttps://www.dovepress.com/immunologic-special-forces-anti-pathogen-cytotoxic-t-lymphocyte-immuno-peer-reviewed-article-ITTimmunotherapystem cell transplantationT cellvirusfungus |
| spellingShingle | Keller MD Bollard CM Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation ImmunoTargets and Therapy immunotherapy stem cell transplantation T cell virus fungus |
| title | Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation |
| title_full | Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation |
| title_fullStr | Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation |
| title_full_unstemmed | Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation |
| title_short | Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation |
| title_sort | immunologic special forces anti pathogen cytotoxic t lymphocyte immunotherapy following hematopoietic stem cell transplantation |
| topic | immunotherapy stem cell transplantation T cell virus fungus |
| url | https://www.dovepress.com/immunologic-special-forces-anti-pathogen-cytotoxic-t-lymphocyte-immuno-peer-reviewed-article-ITT |
| work_keys_str_mv | AT kellermd immunologicspecialforcesantipathogencytotoxictlymphocyteimmunotherapyfollowinghematopoieticstemcelltransplantation AT bollardcm immunologicspecialforcesantipathogencytotoxictlymphocyteimmunotherapyfollowinghematopoieticstemcelltransplantation |