Notch signaling as a master regulator of adult neurogenesis
Neurogenesis ceases in most regions of the mammalian brain before or shortly after birth, however, in a few restricted brain regions, the production of new neurons proceeds into adulthood. Neural stem cells (NSCs) in these neurogenic zones are integrated into niches that control their activity and f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1179011/full |
| _version_ | 1797792461469253632 |
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| author | Aikaterini Lampada Verdon Taylor |
| author_facet | Aikaterini Lampada Verdon Taylor |
| author_sort | Aikaterini Lampada |
| collection | DOAJ |
| description | Neurogenesis ceases in most regions of the mammalian brain before or shortly after birth, however, in a few restricted brain regions, the production of new neurons proceeds into adulthood. Neural stem cells (NSCs) in these neurogenic zones are integrated into niches that control their activity and fate. Most stem cells in the adult brain are mitotically inactive and these cells can remain quiescent for months or even years. One of the key questions is what are the molecular mechanisms that regulate NSC maintenance and differentiation. Notch signaling has been shown to be a critical regulator of stem cell activity and maintenance in many tissues including in the nervous system. In this mini-review we discuss the roles of Notch signaling and the functions of the different Notch receptors and ligands in regulating neurogenesis in the adult murine brain. We review the functions of Notch signaling components in controlling NSC quiescence and entry into cell cycle and neurogenesis. |
| first_indexed | 2024-03-13T02:33:24Z |
| format | Article |
| id | doaj.art-ac240376b39b4e54b32d3353ce00d87b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T02:33:24Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-ac240376b39b4e54b32d3353ce00d87b2023-06-29T10:39:00ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.11790111179011Notch signaling as a master regulator of adult neurogenesisAikaterini LampadaVerdon TaylorNeurogenesis ceases in most regions of the mammalian brain before or shortly after birth, however, in a few restricted brain regions, the production of new neurons proceeds into adulthood. Neural stem cells (NSCs) in these neurogenic zones are integrated into niches that control their activity and fate. Most stem cells in the adult brain are mitotically inactive and these cells can remain quiescent for months or even years. One of the key questions is what are the molecular mechanisms that regulate NSC maintenance and differentiation. Notch signaling has been shown to be a critical regulator of stem cell activity and maintenance in many tissues including in the nervous system. In this mini-review we discuss the roles of Notch signaling and the functions of the different Notch receptors and ligands in regulating neurogenesis in the adult murine brain. We review the functions of Notch signaling components in controlling NSC quiescence and entry into cell cycle and neurogenesis.https://www.frontiersin.org/articles/10.3389/fnins.2023.1179011/fullNotchneural stem cellsneurogenesissubventricular zonedentate gyrus |
| spellingShingle | Aikaterini Lampada Verdon Taylor Notch signaling as a master regulator of adult neurogenesis Frontiers in Neuroscience Notch neural stem cells neurogenesis subventricular zone dentate gyrus |
| title | Notch signaling as a master regulator of adult neurogenesis |
| title_full | Notch signaling as a master regulator of adult neurogenesis |
| title_fullStr | Notch signaling as a master regulator of adult neurogenesis |
| title_full_unstemmed | Notch signaling as a master regulator of adult neurogenesis |
| title_short | Notch signaling as a master regulator of adult neurogenesis |
| title_sort | notch signaling as a master regulator of adult neurogenesis |
| topic | Notch neural stem cells neurogenesis subventricular zone dentate gyrus |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1179011/full |
| work_keys_str_mv | AT aikaterinilampada notchsignalingasamasterregulatorofadultneurogenesis AT verdontaylor notchsignalingasamasterregulatorofadultneurogenesis |