Advances in Intracellular and On‐Surface Polymerization in Living Cells: Implications for Nanobiomedicines
The cellular environment offers some unique features to carry out polymerizations under controlled conditions. Polymerization of monomers in cellular compartments and on the surface of living organisms holds much promise in the engineering of biofunctional synthetic polymers for sensing and probing...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-08-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202200174 |
| _version_ | 1797751941863833600 |
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| author | Partha Laskar Oommen P. Varghese V. Prasad Shastri |
| author_facet | Partha Laskar Oommen P. Varghese V. Prasad Shastri |
| author_sort | Partha Laskar |
| collection | DOAJ |
| description | The cellular environment offers some unique features to carry out polymerizations under controlled conditions. Polymerization of monomers in cellular compartments and on the surface of living organisms holds much promise in the engineering of biofunctional synthetic polymers for sensing and probing cell behavior and of late has received significant interest. This effort lies at the interface of synthetic biology and polymer chemistry and can pave the way for innovative solutions to many existing challenges in healthcare, environment, energy, and the study of the “origin of life”. Herein, recent advances in controlled polymerization strategies for intracellular and surface of living cells are presented with a particular emphasis on nanobiomedicines. Furthermore, polymerization strategies, cytocompatible monomer structures, compatible cell lines and microorganisms, nature of stimulus, catalysts, along with specific polymerization conditions to produce non‐natural biofunctional polymers that can undergo polymerization‐induced self‐assembly within and onto the living cells are presented in detail. Furthermore, the review offers a window into the future of such novel emerging synthetic bionano systems in biomedical sciences. |
| first_indexed | 2024-03-12T16:55:58Z |
| format | Article |
| id | doaj.art-ac2408eed0574d909ce795a8f0369da8 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-03-12T16:55:58Z |
| publishDate | 2023-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-ac2408eed0574d909ce795a8f0369da82023-08-08T06:31:27ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-08-0138n/an/a10.1002/anbr.202200174Advances in Intracellular and On‐Surface Polymerization in Living Cells: Implications for NanobiomedicinesPartha Laskar0Oommen P. Varghese1V. Prasad Shastri2Macromolecular Chemistry Department of Chemistry-Ångström Laboratory Uppsala University Uppsala 752 37 SwedenMacromolecular Chemistry Department of Chemistry-Ångström Laboratory Uppsala University Uppsala 752 37 SwedenInstitute for Macromolecular Chemistry and BIOSS-Centre for Biological Signalling Studies University of Freiburg 79104 Freiburg GermanyThe cellular environment offers some unique features to carry out polymerizations under controlled conditions. Polymerization of monomers in cellular compartments and on the surface of living organisms holds much promise in the engineering of biofunctional synthetic polymers for sensing and probing cell behavior and of late has received significant interest. This effort lies at the interface of synthetic biology and polymer chemistry and can pave the way for innovative solutions to many existing challenges in healthcare, environment, energy, and the study of the “origin of life”. Herein, recent advances in controlled polymerization strategies for intracellular and surface of living cells are presented with a particular emphasis on nanobiomedicines. Furthermore, polymerization strategies, cytocompatible monomer structures, compatible cell lines and microorganisms, nature of stimulus, catalysts, along with specific polymerization conditions to produce non‐natural biofunctional polymers that can undergo polymerization‐induced self‐assembly within and onto the living cells are presented in detail. Furthermore, the review offers a window into the future of such novel emerging synthetic bionano systems in biomedical sciences.https://doi.org/10.1002/anbr.202200174cell surfacescontrolled polymerizationintracellular environmentsliving cells and microorganismsnon-natural polymers |
| spellingShingle | Partha Laskar Oommen P. Varghese V. Prasad Shastri Advances in Intracellular and On‐Surface Polymerization in Living Cells: Implications for Nanobiomedicines Advanced NanoBiomed Research cell surfaces controlled polymerization intracellular environments living cells and microorganisms non-natural polymers |
| title | Advances in Intracellular and On‐Surface Polymerization in Living Cells: Implications for Nanobiomedicines |
| title_full | Advances in Intracellular and On‐Surface Polymerization in Living Cells: Implications for Nanobiomedicines |
| title_fullStr | Advances in Intracellular and On‐Surface Polymerization in Living Cells: Implications for Nanobiomedicines |
| title_full_unstemmed | Advances in Intracellular and On‐Surface Polymerization in Living Cells: Implications for Nanobiomedicines |
| title_short | Advances in Intracellular and On‐Surface Polymerization in Living Cells: Implications for Nanobiomedicines |
| title_sort | advances in intracellular and on surface polymerization in living cells implications for nanobiomedicines |
| topic | cell surfaces controlled polymerization intracellular environments living cells and microorganisms non-natural polymers |
| url | https://doi.org/10.1002/anbr.202200174 |
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