Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term Mortality
Lyudmila Turgunova,1 Irina Mekhantseva,1 Lyudmila Akhmaltdinova,1 Mikhail Kostinov,2,3 Zhibek Zhumadilova,1 Anar Turmukhambetova1 1Karaganda Medical University, Department of Internal Medicine, Karaganda, Kazakhstan; 2I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia; 3Sechenov...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/association-of-strem1-and-neutrophil-to-lymphocyte-ratio-as-prognostic-peer-reviewed-fulltext-article-JIR |
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| author | Turgunova L Mekhantseva I Akhmaltdinova L Kostinov M Zhumadilova Z Turmukhambetova A |
| author_facet | Turgunova L Mekhantseva I Akhmaltdinova L Kostinov M Zhumadilova Z Turmukhambetova A |
| author_sort | Turgunova L |
| collection | DOAJ |
| description | Lyudmila Turgunova,1 Irina Mekhantseva,1 Lyudmila Akhmaltdinova,1 Mikhail Kostinov,2,3 Zhibek Zhumadilova,1 Anar Turmukhambetova1 1Karaganda Medical University, Department of Internal Medicine, Karaganda, Kazakhstan; 2I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia; 3Sechenov First Moscow State Medical University, Department of Epidemiology and Modern Vaccination Technologies, Moscow, RussiaCorrespondence: Irina Mekhantseva, Email Mehanceva@qmu.kzAim: Current problem related to COVID-19 is various complications after disease, especially long-term mortality after COVID-19. Routine blood tests presented their effectiveness in the diagnosis, prognosis and mortality of COVID-19. The neutrophil-to-lymphocyte ratio (NLR) is an important marker of systemic inflammation. Soluble Trigger receptor expressed on myeloid cells-1 (sTREM-1) is considered an intrinsic enhancer of inflammatory signals. This study examined the predictive value of these markers in COVID-19 mortality.Methods: A prospective study was conducted involving patients with COVID-19 in Karaganda, Kazakhstan. The neutrophil–to-lymphocyte ratio (NLR) was calculated as the absolute number of neutrophils divided by the absolute number of lymphocytes. The level of sTREM-1 in the blood serum was evaluated by ELISA.Results: Plasma sTREM-1 concentration greater than 59.08 pg/mL and an NLR greater than 2.29 had an increased risk of early mortality (hazard ratio = 8.07; 95% CI: 1.03– 62.17 and 9.24; 95% CI: 1.202– 71.08, respectively); for long-term mortality of sTREM-1 greater than 47.34 pg/mL (hazard ratio = 7.96; 95% CI: 1.072– 59.18) and NLR greater than 2.10 (hazard ratio = 11.52; 95% CI: 1.551– 85.52).Conclusion: This study suggests that early levels of sTREM-1 and NLR are associated with the risk of 6-month mortality after experiencing COVID-19.Keywords: COVID-19, mortality, neutrophil-to-lymphocyte ratio, sTREM‐1, prognostic markers |
| first_indexed | 2024-03-09T02:45:37Z |
| format | Article |
| id | doaj.art-ac25f156a23a49e2b4ed4a7fc48ef858 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-09T02:45:37Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-ac25f156a23a49e2b4ed4a7fc48ef8582023-12-05T17:06:55ZengDove Medical PressJournal of Inflammation Research1178-70312023-12-01Volume 165807581788700Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term MortalityTurgunova LMekhantseva IAkhmaltdinova LKostinov MZhumadilova ZTurmukhambetova ALyudmila Turgunova,1 Irina Mekhantseva,1 Lyudmila Akhmaltdinova,1 Mikhail Kostinov,2,3 Zhibek Zhumadilova,1 Anar Turmukhambetova1 1Karaganda Medical University, Department of Internal Medicine, Karaganda, Kazakhstan; 2I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia; 3Sechenov First Moscow State Medical University, Department of Epidemiology and Modern Vaccination Technologies, Moscow, RussiaCorrespondence: Irina Mekhantseva, Email Mehanceva@qmu.kzAim: Current problem related to COVID-19 is various complications after disease, especially long-term mortality after COVID-19. Routine blood tests presented their effectiveness in the diagnosis, prognosis and mortality of COVID-19. The neutrophil-to-lymphocyte ratio (NLR) is an important marker of systemic inflammation. Soluble Trigger receptor expressed on myeloid cells-1 (sTREM-1) is considered an intrinsic enhancer of inflammatory signals. This study examined the predictive value of these markers in COVID-19 mortality.Methods: A prospective study was conducted involving patients with COVID-19 in Karaganda, Kazakhstan. The neutrophil–to-lymphocyte ratio (NLR) was calculated as the absolute number of neutrophils divided by the absolute number of lymphocytes. The level of sTREM-1 in the blood serum was evaluated by ELISA.Results: Plasma sTREM-1 concentration greater than 59.08 pg/mL and an NLR greater than 2.29 had an increased risk of early mortality (hazard ratio = 8.07; 95% CI: 1.03– 62.17 and 9.24; 95% CI: 1.202– 71.08, respectively); for long-term mortality of sTREM-1 greater than 47.34 pg/mL (hazard ratio = 7.96; 95% CI: 1.072– 59.18) and NLR greater than 2.10 (hazard ratio = 11.52; 95% CI: 1.551– 85.52).Conclusion: This study suggests that early levels of sTREM-1 and NLR are associated with the risk of 6-month mortality after experiencing COVID-19.Keywords: COVID-19, mortality, neutrophil-to-lymphocyte ratio, sTREM‐1, prognostic markershttps://www.dovepress.com/association-of-strem1-and-neutrophil-to-lymphocyte-ratio-as-prognostic-peer-reviewed-fulltext-article-JIRcovid-19mortalityneutrophil-to-lymphocyte ratiostrem‐1prognostic markers |
| spellingShingle | Turgunova L Mekhantseva I Akhmaltdinova L Kostinov M Zhumadilova Z Turmukhambetova A Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term Mortality Journal of Inflammation Research covid-19 mortality neutrophil-to-lymphocyte ratio strem‐1 prognostic markers |
| title | Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term Mortality |
| title_full | Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term Mortality |
| title_fullStr | Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term Mortality |
| title_full_unstemmed | Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term Mortality |
| title_short | Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term Mortality |
| title_sort | association of strem x2010 1 and neutrophil to lymphocyte ratio as prognostic markers in covid 19 short and long term mortality |
| topic | covid-19 mortality neutrophil-to-lymphocyte ratio strem‐1 prognostic markers |
| url | https://www.dovepress.com/association-of-strem1-and-neutrophil-to-lymphocyte-ratio-as-prognostic-peer-reviewed-fulltext-article-JIR |
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