Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people
Introduction Insulin resistance is becoming an increasingly widespread problem worldwide. For its determination indirect indices of insulin resistance or insulin sensitivity have used. Those indices based on simultaneous measurements of blood glucose and insulin concentrations under fasting conditio...
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| Format: | Article |
| Language: | English |
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Institute of Rural Health
2020-06-01
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| Series: | Annals of Agricultural and Environmental Medicine |
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| Online Access: | http://www.journalssystem.com/aaem/Estimation-of-reference-intervals-of-insulin-resistance-HOMA-insulin-sensitivity,109225,0,2.html |
| _version_ | 1823925809426989056 |
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| author | Sylwia Płaczkowska Lilla Pawlik-Sobecka Izabela Kokot Agnieszka Piwowar |
| author_facet | Sylwia Płaczkowska Lilla Pawlik-Sobecka Izabela Kokot Agnieszka Piwowar |
| author_sort | Sylwia Płaczkowska |
| collection | DOAJ |
| description | Introduction
Insulin resistance is becoming an increasingly widespread problem worldwide. For its determination indirect indices of insulin resistance or insulin sensitivity have used. Those indices based on simultaneous measurements of blood glucose and insulin concentrations under fasting conditions or during the Oral Glucose Tolerance Test.
Objective
The aim of the study was to estimate reliable reference values for the indices used in insulin resistance diagnosis.
Material and methods
Materials and method. 191 selected participants, aged 18–31, were enrolled into the reference population. 130 participants
from the reference population with fasting glucose ≤5.5 mmol/L, BMI<25 kg/m 2 , and without metabolic syndrome, were finally included in the reference group. The following insulin resistance indices were calculated: HOMA1-IR, HOMA2, HOMA2 from C-peptide, QUICKI, Matsuda Index and Insulin Secretion-Sensitive Index-2. Determination of reference intervals for indirect indices of insulin resistance was conducted in accordance with the C28-A3 procedure recommended by the Clinical & Laboratory Standards Institute (CLSI).
Results
Results. The reference intervals for indirect insulin resistance indices examined according to CLSI protocol were: ≤4.00, ≤2.27, ≤4.10, ≥0.31 for HOMA1-IR, HOMA2, HOMA2 C-pep., and QUICKI, respectively. For insulin sensitivity, the value of the Matsuda Index was established as ≥3.19 and for beta cell pancreatic function ISSI-2 as ≥206.
Conclusions
Conclusions. Establishing a reference intervals for these indices enable the proper identification and differentiation of the types of insulin resistance in particular populations. The early detection of metabolic disorders allows for introduction of effective preventive action. |
| first_indexed | 2024-12-16T20:14:45Z |
| format | Article |
| id | doaj.art-ac25f666ee3b4ccb98b77e28f00e010c |
| institution | Directory Open Access Journal |
| issn | 1232-1966 1898-2263 |
| language | English |
| last_indexed | 2024-12-16T20:14:45Z |
| publishDate | 2020-06-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Annals of Agricultural and Environmental Medicine |
| spelling | doaj.art-ac25f666ee3b4ccb98b77e28f00e010c2022-12-21T22:18:01ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632020-06-0127224825410.26444/aaem/109225109225Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young peopleSylwia Płaczkowska0Lilla Pawlik-Sobecka1Izabela Kokot2Agnieszka Piwowar3Diagnostics Laboratory for Teaching and Research, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Medical University, Wroclaw, PolandDepartment of Laboratory Diagnostics, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Medical University, Wroclaw, PolandDepartment of Laboratory Diagnostics, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Medical University, Wroclaw, PolandDepartment of Toxicology, Faculty of Pharmacy with the Division of Laboratory Diagnostics, Medical University, Wroclaw, PolandIntroduction Insulin resistance is becoming an increasingly widespread problem worldwide. For its determination indirect indices of insulin resistance or insulin sensitivity have used. Those indices based on simultaneous measurements of blood glucose and insulin concentrations under fasting conditions or during the Oral Glucose Tolerance Test. Objective The aim of the study was to estimate reliable reference values for the indices used in insulin resistance diagnosis. Material and methods Materials and method. 191 selected participants, aged 18–31, were enrolled into the reference population. 130 participants from the reference population with fasting glucose ≤5.5 mmol/L, BMI<25 kg/m 2 , and without metabolic syndrome, were finally included in the reference group. The following insulin resistance indices were calculated: HOMA1-IR, HOMA2, HOMA2 from C-peptide, QUICKI, Matsuda Index and Insulin Secretion-Sensitive Index-2. Determination of reference intervals for indirect indices of insulin resistance was conducted in accordance with the C28-A3 procedure recommended by the Clinical & Laboratory Standards Institute (CLSI). Results Results. The reference intervals for indirect insulin resistance indices examined according to CLSI protocol were: ≤4.00, ≤2.27, ≤4.10, ≥0.31 for HOMA1-IR, HOMA2, HOMA2 C-pep., and QUICKI, respectively. For insulin sensitivity, the value of the Matsuda Index was established as ≥3.19 and for beta cell pancreatic function ISSI-2 as ≥206. Conclusions Conclusions. Establishing a reference intervals for these indices enable the proper identification and differentiation of the types of insulin resistance in particular populations. The early detection of metabolic disorders allows for introduction of effective preventive action.http://www.journalssystem.com/aaem/Estimation-of-reference-intervals-of-insulin-resistance-HOMA-insulin-sensitivity,109225,0,2.htmlinsulin resistanceyoung adultoral glucose tolerance testreference interval |
| spellingShingle | Sylwia Płaczkowska Lilla Pawlik-Sobecka Izabela Kokot Agnieszka Piwowar Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people Annals of Agricultural and Environmental Medicine insulin resistance young adult oral glucose tolerance test reference interval |
| title | Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people |
| title_full | Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people |
| title_fullStr | Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people |
| title_full_unstemmed | Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people |
| title_short | Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people |
| title_sort | estimation of reference intervals of insulin resistance homa insulin sensitivity matsuda and insulin secretion sensitivity indices issi 2 in polish young people |
| topic | insulin resistance young adult oral glucose tolerance test reference interval |
| url | http://www.journalssystem.com/aaem/Estimation-of-reference-intervals-of-insulin-resistance-HOMA-insulin-sensitivity,109225,0,2.html |
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