Regulation and physiological functions of phoenixin
Phoenixin is a newly discovered neuropeptide generated from small integral membrane protein 20. Phoenixin is a ligand for the G protein-coupled receptor 173 (GPR173) and has been detected in central and peripheral tissues of human, rats, mice, bovine, and zebrafish. It was initially involved in regu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.956500/full |
| _version_ | 1828356157207478272 |
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| author | Han Liang Qian Zhao Shuangyu Lv Xinying Ji |
| author_facet | Han Liang Qian Zhao Shuangyu Lv Xinying Ji |
| author_sort | Han Liang |
| collection | DOAJ |
| description | Phoenixin is a newly discovered neuropeptide generated from small integral membrane protein 20. Phoenixin is a ligand for the G protein-coupled receptor 173 (GPR173) and has been detected in central and peripheral tissues of human, rats, mice, bovine, and zebrafish. It was initially involved in regulating reproductive function by stimulating the luteinizing hormone release from pituitary cells by increasing the level of gonadotropin-releasing hormone. Recently, many functions of phoenixin have been generalized, including regulation of food intake, memory, Alzheimer’s disease, anxiety, inflammation, neuronal and microglial activity, energy metabolism and body fluid balance, cardiovascular function, and endocrine activity. In addition, the interaction between phoenixin and nesfatin-1 have been revealed. The present article summarized the latest research progress on physiological function of phoenixin, suggesting that it is a potential target for novel drug development and clinical application. |
| first_indexed | 2024-04-14T02:54:58Z |
| format | Article |
| id | doaj.art-ac26366659b14779bcc603c94cb31f20 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-14T02:54:58Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-ac26366659b14779bcc603c94cb31f202022-12-22T02:16:10ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-08-01910.3389/fmolb.2022.956500956500Regulation and physiological functions of phoenixinHan Liang0Qian Zhao1Shuangyu Lv2Xinying Ji3The First Affiliated Hospital of Henan University, Henan University, Kaifeng, ChinaInstitute of Molecular Medicine, Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, ChinaInstitute of Molecular Medicine, Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, ChinaInstitute of Molecular Medicine, Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, ChinaPhoenixin is a newly discovered neuropeptide generated from small integral membrane protein 20. Phoenixin is a ligand for the G protein-coupled receptor 173 (GPR173) and has been detected in central and peripheral tissues of human, rats, mice, bovine, and zebrafish. It was initially involved in regulating reproductive function by stimulating the luteinizing hormone release from pituitary cells by increasing the level of gonadotropin-releasing hormone. Recently, many functions of phoenixin have been generalized, including regulation of food intake, memory, Alzheimer’s disease, anxiety, inflammation, neuronal and microglial activity, energy metabolism and body fluid balance, cardiovascular function, and endocrine activity. In addition, the interaction between phoenixin and nesfatin-1 have been revealed. The present article summarized the latest research progress on physiological function of phoenixin, suggesting that it is a potential target for novel drug development and clinical application.https://www.frontiersin.org/articles/10.3389/fmolb.2022.956500/fullphoenixinreproductioninflammationnesfatin-1GPR173 |
| spellingShingle | Han Liang Qian Zhao Shuangyu Lv Xinying Ji Regulation and physiological functions of phoenixin Frontiers in Molecular Biosciences phoenixin reproduction inflammation nesfatin-1 GPR173 |
| title | Regulation and physiological functions of phoenixin |
| title_full | Regulation and physiological functions of phoenixin |
| title_fullStr | Regulation and physiological functions of phoenixin |
| title_full_unstemmed | Regulation and physiological functions of phoenixin |
| title_short | Regulation and physiological functions of phoenixin |
| title_sort | regulation and physiological functions of phoenixin |
| topic | phoenixin reproduction inflammation nesfatin-1 GPR173 |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.956500/full |
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