Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy

Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy

Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered. Fuzi, the lateral roots of Aconitum carmichaelii, shows unique e...

Full description

Bibliographic Details
Main Authors: Ji-Chao Zhou, Cai-Cai Jin, Xiao-Li Wei, Rui-Bing Xu, Ruo-Yu Wang, Zhi-Meng Zhang, Bo Tang, Jin-Mei Yu, Jiao-Jiao Yu, Shuang Shang, Xiao-Xi Lv, Fang Hua, Ping-Ping Li, Zhuo-Wei Hu, Yong-Mei Shen, Feng-Peng Wang, Xiu-Ying Ma, Bing Cui, Fu-Neng Geng, Xiao-Wei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
Aconitum carmichaelii
mitochondrial homeostasis
myocardial energy metabolism
oxidative stress injury
Sqstm1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1118017/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1118017/full

Similar Items