Digging Deeper to Save the Old Anti-tuberculosis Target: D-Alanine–D-Alanine Ligase With a Novel Inhibitor, IMB-0283

Digging Deeper to Save the Old Anti-tuberculosis Target: D-Alanine–D-Alanine Ligase With a Novel Inhibitor, IMB-0283

The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) has hampered treatments for tuberculosis, which consequently now require novel agents to overcome such drug resistance. The genetically stable D-alanine–D-alanine ligase A (DdlA) has been deemed as an excellent therapeutic target for t...

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Bibliographic Details
Main Authors: Jianzhou Meng, Peng Gao, Xiao Wang, Yan Guan, Yishuang Liu, Chunling Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
drug-resistance
D-alanine–D-alanine ligase
inhibitor
D-cycloserine
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.03017/full

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