Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort Study
The independent role of hypertension for COVID-19 outcomes in the population remains unclear. We aimed to estimate the independent effect of hypertension and hypertension-related conditions, i.e., cardiovascular, cerebrovascular and chronic kidney diseases, as potential risk factors for COVID-19 hos...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/6/1194 |
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| author | Ujué Fresán Marcela Guevara Camino Trobajo-Sanmartín Cristina Burgui Carmen Ezpeleta Jesús Castilla |
| author_facet | Ujué Fresán Marcela Guevara Camino Trobajo-Sanmartín Cristina Burgui Carmen Ezpeleta Jesús Castilla |
| author_sort | Ujué Fresán |
| collection | DOAJ |
| description | The independent role of hypertension for COVID-19 outcomes in the population remains unclear. We aimed to estimate the independent effect of hypertension and hypertension-related conditions, i.e., cardiovascular, cerebrovascular and chronic kidney diseases, as potential risk factors for COVID-19 hospitalization and severe COVID-19 (i.e., intensive care unit admission or death) in the population. The risk for severe COVID-19 among hospitalized patients was also evaluated. A Spanish population-based cohort of people aged 25–79 years was prospectively followed from March to May 2020 to identify hospitalizations for laboratory-confirmed COVID-19. Poisson regression was used to estimate the adjusted relative risk (aRR) for COVID-19 hospitalization and severe COVID-19 among the whole cohort, and for severe COVID-19 among hospitalized patients. Of 424,784 people followed, 1106 were hospitalized by COVID-19 and 176 were severe cases. Hypertension was not independently associated with a higher risk of hospitalization (aRR 0.96, 95% CI 0.83–1.12) nor severe COVID-19 (aRR 1.12, 95% CI 0.80–1.56) in the population. Persons with cardiovascular, cerebrovascular and chronic kidney diseases were at higher risk for COVID-19 hospitalization (aRR 1.33, 95% CI 1.13–1.58; aRR 1.41, 95% CI 1.04–1.92; and aRR 1.52, 95% CI 1.21–1.91; respectively) and severe COVID-19 (aRR 1.61, 95% CI 1.13–2.30; aRR 1.91, 95% CI 1.13–3.25; and aRR 1.78, 95% CI 1.14–2.76; respectively). COVID-19 hospitalized patients with cerebrovascular diseases were at higher risk of mortality (aRR 1.80, 95% CI 1.00–3.23). The current study shows that, in the general population, persons with cardiovascular, cerebrovascular and chronic kidney diseases, but not those with hypertension only, should be considered as high-risk groups for COVID-19 hospitalization and severe COVID-19. |
| first_indexed | 2024-03-10T13:17:38Z |
| format | Article |
| id | doaj.art-ac27db6f676c4cea84530c3beccb4bbb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:17:38Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-ac27db6f676c4cea84530c3beccb4bbb2023-11-21T10:16:17ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01106119410.3390/jcm10061194Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort StudyUjué Fresán0Marcela Guevara1Camino Trobajo-Sanmartín2Cristina Burgui3Carmen Ezpeleta4Jesús Castilla5Instituto de Salud Pública de Navarra, 31003 Pamplona, SpainInstituto de Salud Pública de Navarra, 31003 Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, SpainInstituto de Salud Pública de Navarra, 31003 Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, SpainInstituto de Salud Pública de Navarra, 31003 Pamplona, SpainThe independent role of hypertension for COVID-19 outcomes in the population remains unclear. We aimed to estimate the independent effect of hypertension and hypertension-related conditions, i.e., cardiovascular, cerebrovascular and chronic kidney diseases, as potential risk factors for COVID-19 hospitalization and severe COVID-19 (i.e., intensive care unit admission or death) in the population. The risk for severe COVID-19 among hospitalized patients was also evaluated. A Spanish population-based cohort of people aged 25–79 years was prospectively followed from March to May 2020 to identify hospitalizations for laboratory-confirmed COVID-19. Poisson regression was used to estimate the adjusted relative risk (aRR) for COVID-19 hospitalization and severe COVID-19 among the whole cohort, and for severe COVID-19 among hospitalized patients. Of 424,784 people followed, 1106 were hospitalized by COVID-19 and 176 were severe cases. Hypertension was not independently associated with a higher risk of hospitalization (aRR 0.96, 95% CI 0.83–1.12) nor severe COVID-19 (aRR 1.12, 95% CI 0.80–1.56) in the population. Persons with cardiovascular, cerebrovascular and chronic kidney diseases were at higher risk for COVID-19 hospitalization (aRR 1.33, 95% CI 1.13–1.58; aRR 1.41, 95% CI 1.04–1.92; and aRR 1.52, 95% CI 1.21–1.91; respectively) and severe COVID-19 (aRR 1.61, 95% CI 1.13–2.30; aRR 1.91, 95% CI 1.13–3.25; and aRR 1.78, 95% CI 1.14–2.76; respectively). COVID-19 hospitalized patients with cerebrovascular diseases were at higher risk of mortality (aRR 1.80, 95% CI 1.00–3.23). The current study shows that, in the general population, persons with cardiovascular, cerebrovascular and chronic kidney diseases, but not those with hypertension only, should be considered as high-risk groups for COVID-19 hospitalization and severe COVID-19.https://www.mdpi.com/2077-0383/10/6/1194hypertensioncardiovascular diseasecerebrovascular diseasechronic kidney diseaseSARS-CoV-2COVID-19 hospitalization |
| spellingShingle | Ujué Fresán Marcela Guevara Camino Trobajo-Sanmartín Cristina Burgui Carmen Ezpeleta Jesús Castilla Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort Study Journal of Clinical Medicine hypertension cardiovascular disease cerebrovascular disease chronic kidney disease SARS-CoV-2 COVID-19 hospitalization |
| title | Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort Study |
| title_full | Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort Study |
| title_fullStr | Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort Study |
| title_full_unstemmed | Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort Study |
| title_short | Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort Study |
| title_sort | hypertension and related comorbidities as potential risk factors for covid 19 hospitalization and severity a prospective population based cohort study |
| topic | hypertension cardiovascular disease cerebrovascular disease chronic kidney disease SARS-CoV-2 COVID-19 hospitalization |
| url | https://www.mdpi.com/2077-0383/10/6/1194 |
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