Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort Design
Background: Some observational studies show that the consumption of vitamin D is one of the preventive methods which may potentially be useful in the reduction of diabetes type ΙΙ development, insulin resistance, impaired glucose tolerance, and metabolic syndrome. The purpose of this study was to ev...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2013-08-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/2518 |
| _version_ | 1797760922526154752 |
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| author | Mostafa Vahedian Mohammad Reza Maracy Mahmood Parham |
| author_facet | Mostafa Vahedian Mohammad Reza Maracy Mahmood Parham |
| author_sort | Mostafa Vahedian |
| collection | DOAJ |
| description | Background: Some observational studies show that the consumption of vitamin D is one of the preventive methods which may potentially be useful in the reduction of diabetes type ΙΙ development, insulin resistance, impaired glucose tolerance, and metabolic syndrome. The purpose of this study was to evaluate the effect of vitamin D on insulin resistance in patients with type II diabetes.
Methods: This study was conducted as a comprehensive cohort design in Qom, Iran, in 2012. The participants were 120 patients with type II diabetes of whom, 58 agreed to be randomized into two groups and 62 patients were allocated to their preferences. For randomized treatment group, a pill of vitamin D which contained 50000 units was used weekly and orally for duration of 3 months. In the control group, the placebo pill of vitamin D was prescribed by the same method. In the preferential group, patients received neither vitamin D nor placebo. The value of insulin resistance was defined as a score greater than 3.87 in HOMA-IR (Homeostatic model assessment -estimated insulin resistance) index.
Findings: Vitamin D could significantly decrease the HOMA-IR index in the randomized group after controlling for the variables of sex, age, body mass index (BMI), waist, duration of diabetes, heart disease, and HOMA-IR index at the beginning of the study. The reduction was not statistically significant in the preferential group.
Conclusion: Vitamin D can affect the reduction of fasting blood sugar (FBS) and insulin resistance in the randomized group but in the preferential group it cannot. |
| first_indexed | 2024-03-12T19:05:31Z |
| format | Article |
| id | doaj.art-ac2a6e21b4084f749f5804dd85276394 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T19:05:31Z |
| publishDate | 2013-08-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-ac2a6e21b4084f749f5804dd852763942023-08-02T06:18:33ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2013-08-01312397777911350Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort DesignMostafa Vahedian0Mohammad Reza Maracy1Mahmood Parham2MSc Student, Department of Epidemiology and Biostatistics, School of Health AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Clinical Development Research Center, Qom University of Medical Sciences, Qom, IranBackground: Some observational studies show that the consumption of vitamin D is one of the preventive methods which may potentially be useful in the reduction of diabetes type ΙΙ development, insulin resistance, impaired glucose tolerance, and metabolic syndrome. The purpose of this study was to evaluate the effect of vitamin D on insulin resistance in patients with type II diabetes. Methods: This study was conducted as a comprehensive cohort design in Qom, Iran, in 2012. The participants were 120 patients with type II diabetes of whom, 58 agreed to be randomized into two groups and 62 patients were allocated to their preferences. For randomized treatment group, a pill of vitamin D which contained 50000 units was used weekly and orally for duration of 3 months. In the control group, the placebo pill of vitamin D was prescribed by the same method. In the preferential group, patients received neither vitamin D nor placebo. The value of insulin resistance was defined as a score greater than 3.87 in HOMA-IR (Homeostatic model assessment -estimated insulin resistance) index. Findings: Vitamin D could significantly decrease the HOMA-IR index in the randomized group after controlling for the variables of sex, age, body mass index (BMI), waist, duration of diabetes, heart disease, and HOMA-IR index at the beginning of the study. The reduction was not statistically significant in the preferential group. Conclusion: Vitamin D can affect the reduction of fasting blood sugar (FBS) and insulin resistance in the randomized group but in the preferential group it cannot.http://jims.mui.ac.ir/index.php/jims/article/view/2518Vitamin DInsulin resistanceType ΙΙ diabetesComprehensive cohort design |
| spellingShingle | Mostafa Vahedian Mohammad Reza Maracy Mahmood Parham Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort Design مجله دانشکده پزشکی اصفهان Vitamin D Insulin resistance Type ΙΙ diabetes Comprehensive cohort design |
| title | Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort Design |
| title_full | Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort Design |
| title_fullStr | Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort Design |
| title_full_unstemmed | Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort Design |
| title_short | Impact of Vitamin D on Insulin Resistance in Patients with Type ΙΙ Diabetes: A Comprehensive Cohort Design |
| title_sort | impact of vitamin d on insulin resistance in patients with type ιι diabetes a comprehensive cohort design |
| topic | Vitamin D Insulin resistance Type ΙΙ diabetes Comprehensive cohort design |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/2518 |
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