On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sources
Currently, the gold standard for high-resolution mapping of cortical electrophysiological activity is invasive electrocorticography (ECoG), a procedure that carries with it the risk of serious morbidity and mortality. Due to these risks, the use of ECoG is largely limited to pre-surgical mapping in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Neuroimage: Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956022000174 |
| _version_ | 1811257567102369792 |
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| author | Allison C. Nugent Amaia Benitez Andonegui Tom Holroyd Stephen E. Robinson |
| author_facet | Allison C. Nugent Amaia Benitez Andonegui Tom Holroyd Stephen E. Robinson |
| author_sort | Allison C. Nugent |
| collection | DOAJ |
| description | Currently, the gold standard for high-resolution mapping of cortical electrophysiological activity is invasive electrocorticography (ECoG), a procedure that carries with it the risk of serious morbidity and mortality. Due to these risks, the use of ECoG is largely limited to pre-surgical mapping in intractable epilepsy. Nevertheless, many seminal studies in neuroscience have utilized ECoG to explore domains such as visual perception, attention, auditory processing, and sensorimotor behavior. Studies such as these, occurring in patients with epilepsy rather than healthy controls, may lack generalizability, and are limited by the placement of the electrode arrays over the presumed seizure focus. This manuscript explores the use of optically pumped magnetometers (OPMs) to create a non-invasive alternative to ECoG, which we refer to as magnetocorticography. Because prior ECoG studies reveal that most cognitive processes are driven by multiple, simultaneous independent neuronal assemblies, we characterize the ability of a theoretical 56-channel dense OPM array to resolve simultaneous independent sources, and compare it to currently available SQUID devices, as well as OPM arrays with inter-sensor spacings more typical of other systems in development. Our evaluation of this theoretical system assesses many potential sources of error, including errors of sensor calibration and position. In addition, we investigate the influence of geometrical and anatomical factors on array performance. Our simulations reveal the potential of high-density, on-scalp OPM MEG devices to localize electrophysiological brain responses at unprecedented resolution for a non-invasive device. |
| first_indexed | 2024-04-12T17:59:33Z |
| format | Article |
| id | doaj.art-ac2aced164c04fd0ab6840c11b01c05d |
| institution | Directory Open Access Journal |
| issn | 2666-9560 |
| language | English |
| last_indexed | 2024-04-12T17:59:33Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroimage: Reports |
| spelling | doaj.art-ac2aced164c04fd0ab6840c11b01c05d2022-12-22T03:22:13ZengElsevierNeuroimage: Reports2666-95602022-06-0122100093On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sourcesAllison C. Nugent0Amaia Benitez Andonegui1Tom Holroyd2Stephen E. Robinson3Corresponding author.; Magnetoencephlography Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USAMagnetoencephlography Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USAMagnetoencephlography Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USAMagnetoencephlography Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USACurrently, the gold standard for high-resolution mapping of cortical electrophysiological activity is invasive electrocorticography (ECoG), a procedure that carries with it the risk of serious morbidity and mortality. Due to these risks, the use of ECoG is largely limited to pre-surgical mapping in intractable epilepsy. Nevertheless, many seminal studies in neuroscience have utilized ECoG to explore domains such as visual perception, attention, auditory processing, and sensorimotor behavior. Studies such as these, occurring in patients with epilepsy rather than healthy controls, may lack generalizability, and are limited by the placement of the electrode arrays over the presumed seizure focus. This manuscript explores the use of optically pumped magnetometers (OPMs) to create a non-invasive alternative to ECoG, which we refer to as magnetocorticography. Because prior ECoG studies reveal that most cognitive processes are driven by multiple, simultaneous independent neuronal assemblies, we characterize the ability of a theoretical 56-channel dense OPM array to resolve simultaneous independent sources, and compare it to currently available SQUID devices, as well as OPM arrays with inter-sensor spacings more typical of other systems in development. Our evaluation of this theoretical system assesses many potential sources of error, including errors of sensor calibration and position. In addition, we investigate the influence of geometrical and anatomical factors on array performance. Our simulations reveal the potential of high-density, on-scalp OPM MEG devices to localize electrophysiological brain responses at unprecedented resolution for a non-invasive device.http://www.sciencedirect.com/science/article/pii/S2666956022000174MagnetoencephalographyOptically pumped magnetometersSimulation |
| spellingShingle | Allison C. Nugent Amaia Benitez Andonegui Tom Holroyd Stephen E. Robinson On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sources Neuroimage: Reports Magnetoencephalography Optically pumped magnetometers Simulation |
| title | On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sources |
| title_full | On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sources |
| title_fullStr | On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sources |
| title_full_unstemmed | On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sources |
| title_short | On-scalp magnetocorticography with optically pumped magnetometers: Simulated performance in resolving simultaneous sources |
| title_sort | on scalp magnetocorticography with optically pumped magnetometers simulated performance in resolving simultaneous sources |
| topic | Magnetoencephalography Optically pumped magnetometers Simulation |
| url | http://www.sciencedirect.com/science/article/pii/S2666956022000174 |
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