Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

m6A modification has been reported to play roles in many developmental and pathological processes, but its role in AKI remains poorly understood. Here, the authors show the role and the mechanism of the m6A demethylase, ALKBH5 on IRI induced AKI.

Bibliographic Details
Main Authors: Juntao Chen, Cuidi Xu, Kun Yang, Rifeng Gao, Yirui Cao, Lifei Liang, Siyue Chen, Shihao Xu, Ruiming Rong, Jina Wang, Tongyu Zhu
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36747-y

Similar Items

Similar Items