Chondrocytes In Vitro Systems Allowing Study of OA
Osteoarthritis (OA) is an extremely complex disease, as it combines both biological-chemical and mechanical aspects, and it also involves the entire joint consisting of various types of tissues, including cartilage and bone. This paper describes the methods of conducting cell cultures aimed at searc...
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Format: | Article |
Language: | English |
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MDPI AG
2022-09-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/23/18/10308 |
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author | Ewa Bednarczyk |
author_facet | Ewa Bednarczyk |
author_sort | Ewa Bednarczyk |
collection | DOAJ |
description | Osteoarthritis (OA) is an extremely complex disease, as it combines both biological-chemical and mechanical aspects, and it also involves the entire joint consisting of various types of tissues, including cartilage and bone. This paper describes the methods of conducting cell cultures aimed at searching for the mechanical causes of OA development, therapeutic solutions, and methods of preventing the disease. It presents the systems for the cultivation of cartilage cells depending on the level of their structural complexity, and taking into account the most common solutions aimed at recreating the most important factors contributing to the development of OA, that is mechanical loads. In-vitro systems used in tissue engineering to investigate the phenomena associated with OA were specified depending on the complexity and purposefulness of conducting cell cultures. |
first_indexed | 2024-03-09T23:48:57Z |
format | Article |
id | doaj.art-ac2e9cefef6c41078ff7921e2ee189e8 |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-09T23:48:57Z |
publishDate | 2022-09-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-ac2e9cefef6c41078ff7921e2ee189e82023-11-23T16:39:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181030810.3390/ijms231810308Chondrocytes In Vitro Systems Allowing Study of OAEwa Bednarczyk0Faculty of Mechanical and Industrial Engineering, Warsaw University of Technology, Narbutta 85, 02-524 Warsaw, PolandOsteoarthritis (OA) is an extremely complex disease, as it combines both biological-chemical and mechanical aspects, and it also involves the entire joint consisting of various types of tissues, including cartilage and bone. This paper describes the methods of conducting cell cultures aimed at searching for the mechanical causes of OA development, therapeutic solutions, and methods of preventing the disease. It presents the systems for the cultivation of cartilage cells depending on the level of their structural complexity, and taking into account the most common solutions aimed at recreating the most important factors contributing to the development of OA, that is mechanical loads. In-vitro systems used in tissue engineering to investigate the phenomena associated with OA were specified depending on the complexity and purposefulness of conducting cell cultures.https://www.mdpi.com/1422-0067/23/18/10308osteoarthritischondrocyte culturesmechanical loadingtissue engineeringmechanobiologyin-vitro models |
spellingShingle | Ewa Bednarczyk Chondrocytes In Vitro Systems Allowing Study of OA International Journal of Molecular Sciences osteoarthritis chondrocyte cultures mechanical loading tissue engineering mechanobiology in-vitro models |
title | Chondrocytes In Vitro Systems Allowing Study of OA |
title_full | Chondrocytes In Vitro Systems Allowing Study of OA |
title_fullStr | Chondrocytes In Vitro Systems Allowing Study of OA |
title_full_unstemmed | Chondrocytes In Vitro Systems Allowing Study of OA |
title_short | Chondrocytes In Vitro Systems Allowing Study of OA |
title_sort | chondrocytes in vitro systems allowing study of oa |
topic | osteoarthritis chondrocyte cultures mechanical loading tissue engineering mechanobiology in-vitro models |
url | https://www.mdpi.com/1422-0067/23/18/10308 |
work_keys_str_mv | AT ewabednarczyk chondrocytesinvitrosystemsallowingstudyofoa |