Chondrocytes In Vitro Systems Allowing Study of OA

Osteoarthritis (OA) is an extremely complex disease, as it combines both biological-chemical and mechanical aspects, and it also involves the entire joint consisting of various types of tissues, including cartilage and bone. This paper describes the methods of conducting cell cultures aimed at searc...

Full description

Bibliographic Details
Main Author: Ewa Bednarczyk
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/23/18/10308
_version_ 1797487462340100096
author Ewa Bednarczyk
author_facet Ewa Bednarczyk
author_sort Ewa Bednarczyk
collection DOAJ
description Osteoarthritis (OA) is an extremely complex disease, as it combines both biological-chemical and mechanical aspects, and it also involves the entire joint consisting of various types of tissues, including cartilage and bone. This paper describes the methods of conducting cell cultures aimed at searching for the mechanical causes of OA development, therapeutic solutions, and methods of preventing the disease. It presents the systems for the cultivation of cartilage cells depending on the level of their structural complexity, and taking into account the most common solutions aimed at recreating the most important factors contributing to the development of OA, that is mechanical loads. In-vitro systems used in tissue engineering to investigate the phenomena associated with OA were specified depending on the complexity and purposefulness of conducting cell cultures.
first_indexed 2024-03-09T23:48:57Z
format Article
id doaj.art-ac2e9cefef6c41078ff7921e2ee189e8
institution Directory Open Access Journal
issn 1661-6596
1422-0067
language English
last_indexed 2024-03-09T23:48:57Z
publishDate 2022-09-01
publisher MDPI AG
record_format Article
series International Journal of Molecular Sciences
spelling doaj.art-ac2e9cefef6c41078ff7921e2ee189e82023-11-23T16:39:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181030810.3390/ijms231810308Chondrocytes In Vitro Systems Allowing Study of OAEwa Bednarczyk0Faculty of Mechanical and Industrial Engineering, Warsaw University of Technology, Narbutta 85, 02-524 Warsaw, PolandOsteoarthritis (OA) is an extremely complex disease, as it combines both biological-chemical and mechanical aspects, and it also involves the entire joint consisting of various types of tissues, including cartilage and bone. This paper describes the methods of conducting cell cultures aimed at searching for the mechanical causes of OA development, therapeutic solutions, and methods of preventing the disease. It presents the systems for the cultivation of cartilage cells depending on the level of their structural complexity, and taking into account the most common solutions aimed at recreating the most important factors contributing to the development of OA, that is mechanical loads. In-vitro systems used in tissue engineering to investigate the phenomena associated with OA were specified depending on the complexity and purposefulness of conducting cell cultures.https://www.mdpi.com/1422-0067/23/18/10308osteoarthritischondrocyte culturesmechanical loadingtissue engineeringmechanobiologyin-vitro models
spellingShingle Ewa Bednarczyk
Chondrocytes In Vitro Systems Allowing Study of OA
International Journal of Molecular Sciences
osteoarthritis
chondrocyte cultures
mechanical loading
tissue engineering
mechanobiology
in-vitro models
title Chondrocytes In Vitro Systems Allowing Study of OA
title_full Chondrocytes In Vitro Systems Allowing Study of OA
title_fullStr Chondrocytes In Vitro Systems Allowing Study of OA
title_full_unstemmed Chondrocytes In Vitro Systems Allowing Study of OA
title_short Chondrocytes In Vitro Systems Allowing Study of OA
title_sort chondrocytes in vitro systems allowing study of oa
topic osteoarthritis
chondrocyte cultures
mechanical loading
tissue engineering
mechanobiology
in-vitro models
url https://www.mdpi.com/1422-0067/23/18/10308
work_keys_str_mv AT ewabednarczyk chondrocytesinvitrosystemsallowingstudyofoa