Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia
This study aimed to evaluate whether genetic polymorphism is associated with an increased risk of infection, specifically post-stroke aspiration pneumonia. Blood samples were obtained from a total of 206 post-stroke participants (males, <i>n</i> = 136; mean age, 63.8 years). Genotyping w...
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MDPI AG
2022-08-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/8/255 |
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| author | Hae-Yeon Park Hyun-Mi Oh Tae-Woo Kim Youngkook Kim Geun-Young Park Hyemi Hwang Sun Im |
| author_facet | Hae-Yeon Park Hyun-Mi Oh Tae-Woo Kim Youngkook Kim Geun-Young Park Hyemi Hwang Sun Im |
| author_sort | Hae-Yeon Park |
| collection | DOAJ |
| description | This study aimed to evaluate whether genetic polymorphism is associated with an increased risk of infection, specifically post-stroke aspiration pneumonia. Blood samples were obtained from a total of 206 post-stroke participants (males, <i>n</i> = 136; mean age, 63.8 years). Genotyping was performed for catechol-O-methyltransferase (<i>rs4680, rs165599</i>), dopamine receptors (DRD1; <i>rs4532</i>, DRD2; <i>rs1800497</i>, DRD3; <i>rs6280</i>), brain-derived neurotrophic factor (<i>rs6265</i>), apolipoprotein E (<i>rs429358, rs7412</i>), and the interleukin-1 receptor antagonist gene (<i>rs4251961</i>). The subjects were stratified into two groups, aged < 65 (young) and ≥ 65 (elderly). Functional parameters and swallowing outcomes were measured at enrollment and at 3 months post-onset. The primary outcome was the incidence of aspiration pneumonia. Analysis of the association between genetic polymorphisms and aspiration pneumonia history showed that a minor C <i>rs429358</i> allele was associated with the occurrence of aspiration pneumonia in the young group, both in the additive and the dominant models (odds ratio: 4.53; 95% CI: 1.60–12.84, <i>p</i> = 0.004). In the multivariable analysis, the minor C <i>rs429358</i> allele increased the risk of post-stroke aspiration pneumonia in young stroke patients by 5.35 (95% CI: 1.64–20.88). In contrast, no such association was observed in the elderly group. Apolipoprotein E polymorphism may affect the risk of post-stroke aspiration pneumonia. |
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| last_indexed | 2024-03-09T04:35:09Z |
| publishDate | 2022-08-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj.art-ac2fa4a7bc504d3baff44ec0668f760e2023-12-03T13:29:05ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-08-014483735374510.3390/cimb44080255Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with DysphagiaHae-Yeon Park0Hyun-Mi Oh1Tae-Woo Kim2Youngkook Kim3Geun-Young Park4Hyemi Hwang5Sun Im6Department of Rehabilitation Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, National Traffic Injury Rehabilitation Hospital, Yangpyeong 12564, KoreaDepartment of Rehabilitation Medicine, National Traffic Injury Rehabilitation Hospital, Yangpyeong 12564, KoreaDepartment of Rehabilitation Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, KoreaDepartment of Rehabilitation Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 14647, KoreaDepartment of Rehabilitation Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 14647, KoreaDepartment of Rehabilitation Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 14647, KoreaThis study aimed to evaluate whether genetic polymorphism is associated with an increased risk of infection, specifically post-stroke aspiration pneumonia. Blood samples were obtained from a total of 206 post-stroke participants (males, <i>n</i> = 136; mean age, 63.8 years). Genotyping was performed for catechol-O-methyltransferase (<i>rs4680, rs165599</i>), dopamine receptors (DRD1; <i>rs4532</i>, DRD2; <i>rs1800497</i>, DRD3; <i>rs6280</i>), brain-derived neurotrophic factor (<i>rs6265</i>), apolipoprotein E (<i>rs429358, rs7412</i>), and the interleukin-1 receptor antagonist gene (<i>rs4251961</i>). The subjects were stratified into two groups, aged < 65 (young) and ≥ 65 (elderly). Functional parameters and swallowing outcomes were measured at enrollment and at 3 months post-onset. The primary outcome was the incidence of aspiration pneumonia. Analysis of the association between genetic polymorphisms and aspiration pneumonia history showed that a minor C <i>rs429358</i> allele was associated with the occurrence of aspiration pneumonia in the young group, both in the additive and the dominant models (odds ratio: 4.53; 95% CI: 1.60–12.84, <i>p</i> = 0.004). In the multivariable analysis, the minor C <i>rs429358</i> allele increased the risk of post-stroke aspiration pneumonia in young stroke patients by 5.35 (95% CI: 1.64–20.88). In contrast, no such association was observed in the elderly group. Apolipoprotein E polymorphism may affect the risk of post-stroke aspiration pneumonia.https://www.mdpi.com/1467-3045/44/8/255deglutitionaspiration pneumoniasingle nucleotide polymorphismsstrokedysphagia |
| spellingShingle | Hae-Yeon Park Hyun-Mi Oh Tae-Woo Kim Youngkook Kim Geun-Young Park Hyemi Hwang Sun Im Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia Current Issues in Molecular Biology deglutition aspiration pneumonia single nucleotide polymorphisms stroke dysphagia |
| title | Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia |
| title_full | Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia |
| title_fullStr | Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia |
| title_full_unstemmed | Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia |
| title_short | Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia |
| title_sort | single nucleotide polymorphisms may increase the risk of aspiration pneumonia in post stroke patients with dysphagia |
| topic | deglutition aspiration pneumonia single nucleotide polymorphisms stroke dysphagia |
| url | https://www.mdpi.com/1467-3045/44/8/255 |
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