Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs
Abstract The objective of this study was to synthesize and characterize pharmaceutical characteristics of florfenicol sustained-release granules (FSRGs) in vitro and in vivo. FSRGs were synthesized using monostearate, polyethylene glycol 4000 and starch. In vitro dissolution profiles were studied us...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12917-023-03631-2 |
| _version_ | 1797789721918701568 |
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| author | Wei-cong Yang Zi-yao Liu Yun-xiao Zhang Yang Yu Yue Shen Ying Xu Xian-hui Huang |
| author_facet | Wei-cong Yang Zi-yao Liu Yun-xiao Zhang Yang Yu Yue Shen Ying Xu Xian-hui Huang |
| author_sort | Wei-cong Yang |
| collection | DOAJ |
| description | Abstract The objective of this study was to synthesize and characterize pharmaceutical characteristics of florfenicol sustained-release granules (FSRGs) in vitro and in vivo. FSRGs were synthesized using monostearate, polyethylene glycol 4000 and starch. In vitro dissolution profiles were studied using the rotating basket method in pH 1.2 HCl solution and pH 4.3 acetate buffer. Twenty-four male healthy Landrace×Yorkshire pigs were equally divided into three groups and administered a 20 mg/kg i.v bolus of florfenicol solution and dosed orally with FSRGs in the fasting and fed states. The Higuchi model was the best fit for the drug release profile in pH 1.2 and pH 4.3 media, and the mechanism of drug dissolution was governed by both diffusion and dissolution. We established a level A in vitro - in vivo correlation for FSRGs and the in vivo profile of the FSRGs can be estimated by the in vitro drug release. |
| first_indexed | 2024-03-13T01:54:42Z |
| format | Article |
| id | doaj.art-ac316589d1654b048258cb3ad647c877 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-03-13T01:54:42Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-ac316589d1654b048258cb3ad647c8772023-07-02T11:18:34ZengBMCBMC Veterinary Research1746-61482023-06-0119111010.1186/s12917-023-03631-2Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigsWei-cong Yang0Zi-yao Liu1Yun-xiao Zhang2Yang Yu3Yue Shen4Ying Xu5Xian-hui Huang6Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural UniversityVeterinary Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural UniversityVeterinary Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural UniversityVeterinary Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural UniversityVeterinary Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural UniversityVeterinary Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural UniversityVeterinary Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural UniversityAbstract The objective of this study was to synthesize and characterize pharmaceutical characteristics of florfenicol sustained-release granules (FSRGs) in vitro and in vivo. FSRGs were synthesized using monostearate, polyethylene glycol 4000 and starch. In vitro dissolution profiles were studied using the rotating basket method in pH 1.2 HCl solution and pH 4.3 acetate buffer. Twenty-four male healthy Landrace×Yorkshire pigs were equally divided into three groups and administered a 20 mg/kg i.v bolus of florfenicol solution and dosed orally with FSRGs in the fasting and fed states. The Higuchi model was the best fit for the drug release profile in pH 1.2 and pH 4.3 media, and the mechanism of drug dissolution was governed by both diffusion and dissolution. We established a level A in vitro - in vivo correlation for FSRGs and the in vivo profile of the FSRGs can be estimated by the in vitro drug release.https://doi.org/10.1186/s12917-023-03631-2PharmacokineticOral deliveryIn vitro-in vivo correlationPigFlorfenicol |
| spellingShingle | Wei-cong Yang Zi-yao Liu Yun-xiao Zhang Yang Yu Yue Shen Ying Xu Xian-hui Huang Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs BMC Veterinary Research Pharmacokinetic Oral delivery In vitro-in vivo correlation Pig Florfenicol |
| title | Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs |
| title_full | Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs |
| title_fullStr | Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs |
| title_full_unstemmed | Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs |
| title_short | Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs |
| title_sort | florfenicol sustained release granules an in vitro in vivo correlation study in pigs |
| topic | Pharmacokinetic Oral delivery In vitro-in vivo correlation Pig Florfenicol |
| url | https://doi.org/10.1186/s12917-023-03631-2 |
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