Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia
ObjectiveTo explore the relationship between the Duration of Untreated Psychosis (DUP) and long-term clinical outcome, cognitive and social function in patients with chronic schizophrenia (SCZ).MethodsA total of 248 subjects with chronic SCZ were enrolled in this study, including 156 in the short DU...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1112657/full |
| _version_ | 1797905140688093184 |
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| author | Minglan Yu Qingyu Tan Qingyu Tan Yan Wang Yi Xu Tingting Wang Dongmei Liu Dechao Chen Peiying Deng Chaohua Huang Xuemei Liang Kezhi Liu Bo Xiang Bo Xiang Bo Xiang |
| author_facet | Minglan Yu Qingyu Tan Qingyu Tan Yan Wang Yi Xu Tingting Wang Dongmei Liu Dechao Chen Peiying Deng Chaohua Huang Xuemei Liang Kezhi Liu Bo Xiang Bo Xiang Bo Xiang |
| author_sort | Minglan Yu |
| collection | DOAJ |
| description | ObjectiveTo explore the relationship between the Duration of Untreated Psychosis (DUP) and long-term clinical outcome, cognitive and social function in patients with chronic schizophrenia (SCZ).MethodsA total of 248 subjects with chronic SCZ were enrolled in this study, including 156 in the short DUP group and 92 in the long DUP group. The Positive and Negative Symptoms Scale (PANSS), the Brief Negative Symptoms Scale (BNSS), the Global Assessment of Functioning (GAF) scale and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were used to assess all of the subjects.ResultsThe negative symptom scores (the PANSS and BNSS) of subjects with long DUP were significantly higher than that in subjects with short DUP. The scores of visual span and speech function in the short DUP group were significantly higher, indicative of decreasing cognitive function with time. In terms of social function, the short DUP group scored higher, with a statistically significant difference. Meanwhile, we found that the length of DUP was positively correlated with the negative symptom score of the PANSS, negatively correlated with visual span scores, and GAF scores.ConclusionThis study demonstrated that the DUP remained a significant association with negative symptom and cognition in long period of chronic SCZ. |
| first_indexed | 2024-04-10T10:00:20Z |
| format | Article |
| id | doaj.art-ac3350d4c0bc4586822cb71f905fbdbd |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-10T10:00:20Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-ac3350d4c0bc4586822cb71f905fbdbd2023-02-16T08:57:08ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-02-011410.3389/fpsyt.2023.11126571112657Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophreniaMinglan Yu0Qingyu Tan1Qingyu Tan2Yan Wang3Yi Xu4Tingting Wang5Dongmei Liu6Dechao Chen7Peiying Deng8Chaohua Huang9Xuemei Liang10Kezhi Liu11Bo Xiang12Bo Xiang13Bo Xiang14Department of Psychiatry, Laboratory of Neurological Diseases and Brain Function, Medical Laboratory Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Psychiatry, Laboratory of Neurological Diseases and Brain Function, Medical Laboratory Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Psychosomatic Medicine, People’s Hospital of Deyang City, Deyang, Sichuan, ChinaDepartment of Psychiatry, Laboratory of Neurological Diseases and Brain Function, Medical Laboratory Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Psychiatry, Laboratory of Neurological Diseases and Brain Function, Medical Laboratory Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Psychiatry, Yibin Fourth People’s Hospital, Yibin, Sichuan, ChinaDepartment of Psychiatry, Yibin Fourth People’s Hospital, Yibin, Sichuan, ChinaDepartment of Psychiatry, Yibin Fourth People’s Hospital, Yibin, Sichuan, ChinaDepartment of Psychiatry, Laboratory of Neurological Diseases and Brain Function, Medical Laboratory Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Psychiatry, Laboratory of Neurological Diseases and Brain Function, Medical Laboratory Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Psychiatry, Laboratory of Neurological Diseases and Brain Function, Medical Laboratory Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Psychiatry, Laboratory of Neurological Diseases and Brain Function, Medical Laboratory Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaInstitute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, ChinaCentral Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaObjectiveTo explore the relationship between the Duration of Untreated Psychosis (DUP) and long-term clinical outcome, cognitive and social function in patients with chronic schizophrenia (SCZ).MethodsA total of 248 subjects with chronic SCZ were enrolled in this study, including 156 in the short DUP group and 92 in the long DUP group. The Positive and Negative Symptoms Scale (PANSS), the Brief Negative Symptoms Scale (BNSS), the Global Assessment of Functioning (GAF) scale and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were used to assess all of the subjects.ResultsThe negative symptom scores (the PANSS and BNSS) of subjects with long DUP were significantly higher than that in subjects with short DUP. The scores of visual span and speech function in the short DUP group were significantly higher, indicative of decreasing cognitive function with time. In terms of social function, the short DUP group scored higher, with a statistically significant difference. Meanwhile, we found that the length of DUP was positively correlated with the negative symptom score of the PANSS, negatively correlated with visual span scores, and GAF scores.ConclusionThis study demonstrated that the DUP remained a significant association with negative symptom and cognition in long period of chronic SCZ.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1112657/fullduration of untreated psychosis (DUP)schizophreniacognitionclinical symptomlong-term prognosis |
| spellingShingle | Minglan Yu Qingyu Tan Qingyu Tan Yan Wang Yi Xu Tingting Wang Dongmei Liu Dechao Chen Peiying Deng Chaohua Huang Xuemei Liang Kezhi Liu Bo Xiang Bo Xiang Bo Xiang Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia Frontiers in Psychiatry duration of untreated psychosis (DUP) schizophrenia cognition clinical symptom long-term prognosis |
| title | Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia |
| title_full | Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia |
| title_fullStr | Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia |
| title_full_unstemmed | Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia |
| title_short | Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia |
| title_sort | correlation between duration of untreated psychosis and long term prognosis in chronic schizophrenia |
| topic | duration of untreated psychosis (DUP) schizophrenia cognition clinical symptom long-term prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1112657/full |
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