The association between rapid growth and lipid profile: a systematic review and meta-analysis
Background & aimsMetabolic disease prevalence has increased in many regions, and is closely associated with dyslipidemia. Rapid growth refers to a significant increase in growth velocity above the normal range, particularly in infants and children, and is highly prevalent in congenital defic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1353334/full |
| _version_ | 1827312407546953728 |
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| author | Botian Chen Yunli Chen Yuyang Wang Qinghua Xin Defu Ma |
| author_facet | Botian Chen Yunli Chen Yuyang Wang Qinghua Xin Defu Ma |
| author_sort | Botian Chen |
| collection | DOAJ |
| description | Background & aimsMetabolic disease prevalence has increased in many regions, and is closely associated with dyslipidemia. Rapid growth refers to a significant increase in growth velocity above the normal range, particularly in infants and children, and is highly prevalent in congenital deficiency infants. But the association between dyslipidemia and rapid growth remains controversial. We performed this meta-analysis to investigate the lipid profile in subjects with and without postnatal rapid growth, and to determine what are the confounding factors.MethodsMedline, EMBASE, China National Knowledge Infrastructure Chinese citation database and WANFANG database were searched (last search in May 2021). Publication bias was examined by constructing funnel plots, Egger’s linear regression test and Begg’s rank correlation test.ResultsThe fixed effects model would be adopted if I2 is less than 25%, otherwise random effects model would be used. There were 11 articles involved with a total of 1148 participants (539 boys and 609 girls, mean age=7.4 years). Pooled analysis found that rapid growth was negatively associated with high-density lipoprotein cholesterol (HDL-C) (weighted mean difference=-0.068, 95%CI [-0.117, -0.020]), but not associated with triglycerides (TG), total cholesterol (TC), or low-density lipoprotein cholesterol (LDL-C). Stratified analysis suggested that increased TG were found in rapid growth subjects from developing countries. Higher TC was observed for rapid growth participants of follow-up age ≤8 years old, rapid growth duration ≤2 years, preterm, low birth weight, and from developing countries. But decreased TC was observed in small for gestational age (SGA) rapid growth subjects. Decreased LDL-C had been documented in rapid growth subjects of follow-up age >8 years old, from developed countries, and SGA. At last, rapid growth groups had lower HDL-C in infants of rapid growth duration >2 years and from developed countries.ConclusionRapid growth is associated with lipid profiles, particularly during early childhood, and this relationship is influenced by factors such as the duration of growth, the level of national development, and birth weight. These findings are significant for the development of strategies to prevent metabolic diseases.This review was registered in PROSPERO International Prospective Register of Systematic Reviews (www.crd.york.ac.uk/prospero/) with the registration number CRD42020154240. |
| first_indexed | 2024-04-24T21:42:52Z |
| format | Article |
| id | doaj.art-ac34beb7bd3b4e1e9fe005a57b20addf |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T21:42:52Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ac34beb7bd3b4e1e9fe005a57b20addf2024-03-21T05:13:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13533341353334The association between rapid growth and lipid profile: a systematic review and meta-analysisBotian Chen0Yunli Chen1Yuyang Wang2Qinghua Xin3Defu Ma4School of Public Health, Peking University Health Science Center, Beijing, ChinaSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaSchool of Public Health, Peking University Health Science Center, Beijing, ChinaShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, ChinaSchool of Public Health, Peking University Health Science Center, Beijing, ChinaBackground & aimsMetabolic disease prevalence has increased in many regions, and is closely associated with dyslipidemia. Rapid growth refers to a significant increase in growth velocity above the normal range, particularly in infants and children, and is highly prevalent in congenital deficiency infants. But the association between dyslipidemia and rapid growth remains controversial. We performed this meta-analysis to investigate the lipid profile in subjects with and without postnatal rapid growth, and to determine what are the confounding factors.MethodsMedline, EMBASE, China National Knowledge Infrastructure Chinese citation database and WANFANG database were searched (last search in May 2021). Publication bias was examined by constructing funnel plots, Egger’s linear regression test and Begg’s rank correlation test.ResultsThe fixed effects model would be adopted if I2 is less than 25%, otherwise random effects model would be used. There were 11 articles involved with a total of 1148 participants (539 boys and 609 girls, mean age=7.4 years). Pooled analysis found that rapid growth was negatively associated with high-density lipoprotein cholesterol (HDL-C) (weighted mean difference=-0.068, 95%CI [-0.117, -0.020]), but not associated with triglycerides (TG), total cholesterol (TC), or low-density lipoprotein cholesterol (LDL-C). Stratified analysis suggested that increased TG were found in rapid growth subjects from developing countries. Higher TC was observed for rapid growth participants of follow-up age ≤8 years old, rapid growth duration ≤2 years, preterm, low birth weight, and from developing countries. But decreased TC was observed in small for gestational age (SGA) rapid growth subjects. Decreased LDL-C had been documented in rapid growth subjects of follow-up age >8 years old, from developed countries, and SGA. At last, rapid growth groups had lower HDL-C in infants of rapid growth duration >2 years and from developed countries.ConclusionRapid growth is associated with lipid profiles, particularly during early childhood, and this relationship is influenced by factors such as the duration of growth, the level of national development, and birth weight. These findings are significant for the development of strategies to prevent metabolic diseases.This review was registered in PROSPERO International Prospective Register of Systematic Reviews (www.crd.york.ac.uk/prospero/) with the registration number CRD42020154240.https://www.frontiersin.org/articles/10.3389/fendo.2024.1353334/fullrapid growthtriglyceridetotal cholesterollow density lipoproteinhigh density lipoprotein |
| spellingShingle | Botian Chen Yunli Chen Yuyang Wang Qinghua Xin Defu Ma The association between rapid growth and lipid profile: a systematic review and meta-analysis Frontiers in Endocrinology rapid growth triglyceride total cholesterol low density lipoprotein high density lipoprotein |
| title | The association between rapid growth and lipid profile: a systematic review and meta-analysis |
| title_full | The association between rapid growth and lipid profile: a systematic review and meta-analysis |
| title_fullStr | The association between rapid growth and lipid profile: a systematic review and meta-analysis |
| title_full_unstemmed | The association between rapid growth and lipid profile: a systematic review and meta-analysis |
| title_short | The association between rapid growth and lipid profile: a systematic review and meta-analysis |
| title_sort | association between rapid growth and lipid profile a systematic review and meta analysis |
| topic | rapid growth triglyceride total cholesterol low density lipoprotein high density lipoprotein |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1353334/full |
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