Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis
Introduction. Determining the levels of S100A8 proteins (alias: MRP8), S100A9 (alias: MRP14) may contribute to early diagnosis of systemic arthritis in children. The objective of the study was to compare blood levels of calprotectin (MRP8/14 (S100A8/9)) in patients with systemic, polyarticular, RF-n...
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Zaslavsky O.Yu.
2016-10-01
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| Series: | Zdorovʹe Rebenka |
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| Online Access: | http://childshealth.zaslavsky.com.ua/article/view/86719 |
| _version_ | 1819293947316404224 |
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| author | Ya.Ye. Boiko |
| author_facet | Ya.Ye. Boiko |
| author_sort | Ya.Ye. Boiko |
| collection | DOAJ |
| description | Introduction. Determining the levels of S100A8 proteins (alias: MRP8), S100A9 (alias: MRP14) may contribute to early diagnosis of systemic arthritis in children. The objective of the study was to compare blood levels of calprotectin (MRP8/14 (S100A8/9)) in patients with systemic, polyarticular, RF-negative and oligoarticular types of juvenile idiopathic arthritis (JIA) in the active stage of the disease and to investigate the correlation between blood levels of calprotectin (MRP8/14 (S100A8/9)) with clinical and laboratory markers of JIA activity. Results. It was shown that calprotectin blood level was higher in patients with systemic course of the disease (median 13,800 ng/ml) and was significantly different from that of healthy children (median 1,800 ng/ml, p = 0.00002), indicators of patients with articular forms of JIA (median 2,700 ng/ml,
p = 0.000008), patients with polyarthritis and negative RF (median 3,800 ng/ml, p = 0.003226) and oligoarthritis (median 2,500 ng/ml, p = 0.000009). The highest calprotectin levels in the blood were found in patients with newly diagnosed systemic JIA: the median was 32,500 ng/ml (from 13,800 to 177,000 ng/ml).
A direct correlation of blood calprotectin was established with the rate of JADAS 27 blood activity (p = 0.000009), erythrocyte sedimentation rate (p = 0.000079) and C-reactive protein (p = 0.000058). Conclusions. Calprotectin level in the blood (MRP8/MRP14) (MRP8/14 (S100A8/9)) is one of the indicators that can be used to confirm the diagnosis of systemic JIA and to monitor the activity and effectiveness of therapy. |
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| publishDate | 2016-10-01 |
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| spelling | doaj.art-ac3564ef65c14e498be027825e81371b2022-12-21T17:15:52ZengZaslavsky O.Yu.Zdorovʹe Rebenka2224-05512307-11682016-10-01117.75182410.22141/2224-0551.7.75.2016.8671986719Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic ArthritisYa.Ye. Boiko0Municipal Institution of Lviv Regional Council «West-Ukrainian Specialized Children’s Medical Center », Lviv, Ukraine Lviv National Medical University named after Danylo Halytskyi, Lviv, UkraineIntroduction. Determining the levels of S100A8 proteins (alias: MRP8), S100A9 (alias: MRP14) may contribute to early diagnosis of systemic arthritis in children. The objective of the study was to compare blood levels of calprotectin (MRP8/14 (S100A8/9)) in patients with systemic, polyarticular, RF-negative and oligoarticular types of juvenile idiopathic arthritis (JIA) in the active stage of the disease and to investigate the correlation between blood levels of calprotectin (MRP8/14 (S100A8/9)) with clinical and laboratory markers of JIA activity. Results. It was shown that calprotectin blood level was higher in patients with systemic course of the disease (median 13,800 ng/ml) and was significantly different from that of healthy children (median 1,800 ng/ml, p = 0.00002), indicators of patients with articular forms of JIA (median 2,700 ng/ml, p = 0.000008), patients with polyarthritis and negative RF (median 3,800 ng/ml, p = 0.003226) and oligoarthritis (median 2,500 ng/ml, p = 0.000009). The highest calprotectin levels in the blood were found in patients with newly diagnosed systemic JIA: the median was 32,500 ng/ml (from 13,800 to 177,000 ng/ml). A direct correlation of blood calprotectin was established with the rate of JADAS 27 blood activity (p = 0.000009), erythrocyte sedimentation rate (p = 0.000079) and C-reactive protein (p = 0.000058). Conclusions. Calprotectin level in the blood (MRP8/MRP14) (MRP8/14 (S100A8/9)) is one of the indicators that can be used to confirm the diagnosis of systemic JIA and to monitor the activity and effectiveness of therapy.http://childshealth.zaslavsky.com.ua/article/view/86719juvenile idiopathic arthritisMRP8/MRP14blood calprotectinbiomarkerscytokinespathogenesis |
| spellingShingle | Ya.Ye. Boiko Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis Zdorovʹe Rebenka juvenile idiopathic arthritis MRP8/MRP14 blood calprotectin biomarkers cytokines pathogenesis |
| title | Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis |
| title_full | Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis |
| title_fullStr | Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis |
| title_full_unstemmed | Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis |
| title_short | Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis |
| title_sort | diagnostic and prognostic value of calprotectin mrp8 mrp14 in the blood of patients with different types of juvenile idiopathic arthritis |
| topic | juvenile idiopathic arthritis MRP8/MRP14 blood calprotectin biomarkers cytokines pathogenesis |
| url | http://childshealth.zaslavsky.com.ua/article/view/86719 |
| work_keys_str_mv | AT yayeboiko diagnosticandprognosticvalueofcalprotectinmrp8mrp14inthebloodofpatientswithdifferenttypesofjuvenileidiopathicarthritis |