Dendritic Cell-Restricted Progenitors Contribute to Obesity-Associated Airway Inflammation via Adam17-p38 MAPK-Dependent Pathway

Dendritic Cell-Restricted Progenitors Contribute to Obesity-Associated Airway Inflammation via Adam17-p38 MAPK-Dependent Pathway

Proliferation of dendritic cell (DC)—restricted progenitor cells in bone marrow compartment is tightly regulated at steady state and responds to multiple tissue-specific triggers during disturbed homeostasis such as obesity. DCs in the lung stem from a rapidly dividing DC-restricted progenitor cells...

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Bibliographic Details
Main Authors: Anil Kumar Jaiswal, Sangeet Makhija, Natalie Stahr, Maninder Sandey, Amol Suryawanshi, Ankit Saxena, Pradeep K. Dagur, J. Philip McCoy, Stewart J. Levine, Amarjit Mishra
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
dendritic cell-restricted progenitors
CDPs
obesity
asthma
Adam17
p38 MAPK pathway
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00363/full

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