Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications
In recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness and the greatest possible automation. Some of the factors that challe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00827/full |
| _version_ | 1811223929204768768 |
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| author | Luis Abelardo Villarruel Mendoza Natalia Antonela Scilletta Martin Gonzalo Bellino Martin Federico Desimone Paolo Nicolas Catalano Paolo Nicolas Catalano |
| author_facet | Luis Abelardo Villarruel Mendoza Natalia Antonela Scilletta Martin Gonzalo Bellino Martin Federico Desimone Paolo Nicolas Catalano Paolo Nicolas Catalano |
| author_sort | Luis Abelardo Villarruel Mendoza |
| collection | DOAJ |
| description | In recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness and the greatest possible automation. Some of the factors that challenge conventional drug release include long-term treatments, narrow therapeutic windows, complex dosing schedules, combined therapies, individual dosing regimens, and labile active substance administration. In this sense, the emergence of micro-devices that combine mechanical and electrical components, so called micro-electro-mechanical systems (MEMS) can offer solutions to these drawbacks. These devices can be fabricated using biocompatible materials, with great uniformity and reproducibility, similar to integrated circuits. They can be aseptically manufactured and hermetically sealed, while having mobile components that enable physical or analytical functions together with electrical components. In this review we present recent advances in the generation of MEMS drug delivery devices, in which various micro and nanometric structures such as contacts, connections, channels, reservoirs, pumps, valves, needles, and/or membranes can be included in their design and manufacture. Implantable single and multiple reservoir-based and transdermal-based MEMS devices are discussed in terms of fundamental mechanisms, fabrication, performance, and drug release applications. |
| first_indexed | 2024-04-12T08:42:01Z |
| format | Article |
| id | doaj.art-ac37dd0d22104f27a1aa4190d653d927 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T08:42:01Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-ac37dd0d22104f27a1aa4190d653d9272022-12-22T03:39:52ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-07-01810.3389/fbioe.2020.00827556016Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release ApplicationsLuis Abelardo Villarruel Mendoza0Natalia Antonela Scilletta1Martin Gonzalo Bellino2Martin Federico Desimone3Paolo Nicolas Catalano4Paolo Nicolas Catalano5Departamento de Micro y Nanotecnologia, Instituto de Nanociencia y Nanotecnología, CNEA-CONICET, San Martín, ArgentinaDepartamento de Micro y Nanotecnologia, Instituto de Nanociencia y Nanotecnología, CNEA-CONICET, San Martín, ArgentinaInstituto de Nanociencia y Nanotecnología, CNEA-CONICET, San Martín, ArgentinaUniversidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica, Buenos Aires, ArgentinaDepartamento de Micro y Nanotecnologia, Instituto de Nanociencia y Nanotecnología, CNEA-CONICET, San Martín, ArgentinaUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Buenos Aires, ArgentinaIn recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness and the greatest possible automation. Some of the factors that challenge conventional drug release include long-term treatments, narrow therapeutic windows, complex dosing schedules, combined therapies, individual dosing regimens, and labile active substance administration. In this sense, the emergence of micro-devices that combine mechanical and electrical components, so called micro-electro-mechanical systems (MEMS) can offer solutions to these drawbacks. These devices can be fabricated using biocompatible materials, with great uniformity and reproducibility, similar to integrated circuits. They can be aseptically manufactured and hermetically sealed, while having mobile components that enable physical or analytical functions together with electrical components. In this review we present recent advances in the generation of MEMS drug delivery devices, in which various micro and nanometric structures such as contacts, connections, channels, reservoirs, pumps, valves, needles, and/or membranes can be included in their design and manufacture. Implantable single and multiple reservoir-based and transdermal-based MEMS devices are discussed in terms of fundamental mechanisms, fabrication, performance, and drug release applications.https://www.frontiersin.org/article/10.3389/fbioe.2020.00827/fullmicro-electro-mechanical systemsdrug deliverymicrofabricationimplantable MEMS devicesactuation mechanismstransdermal devices |
| spellingShingle | Luis Abelardo Villarruel Mendoza Natalia Antonela Scilletta Martin Gonzalo Bellino Martin Federico Desimone Paolo Nicolas Catalano Paolo Nicolas Catalano Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications Frontiers in Bioengineering and Biotechnology micro-electro-mechanical systems drug delivery microfabrication implantable MEMS devices actuation mechanisms transdermal devices |
| title | Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications |
| title_full | Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications |
| title_fullStr | Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications |
| title_full_unstemmed | Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications |
| title_short | Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications |
| title_sort | recent advances in micro electro mechanical devices for controlled drug release applications |
| topic | micro-electro-mechanical systems drug delivery microfabrication implantable MEMS devices actuation mechanisms transdermal devices |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.00827/full |
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