Fatal <i>Lodderomyces elongisporus</i> Fungemia in a Premature, Extremely Low-Birth-Weight Neonate
Many rare yeasts are emerging as pathogens, causing invasive infections in susceptible hosts that are associated with poor clinical outcome. Here, we describe the first and fatal case of <i>Lodderomyces elongisporus</i> fungemia in a premature, extremely low-birth-weight neonate after sp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/9/906 |
| _version_ | 1797486242719334400 |
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| author | Mohammad Asadzadeh Noura Al-Sweih Suhail Ahmad Seema Khan Wadha Alfouzan Leena Joseph |
| author_facet | Mohammad Asadzadeh Noura Al-Sweih Suhail Ahmad Seema Khan Wadha Alfouzan Leena Joseph |
| author_sort | Mohammad Asadzadeh |
| collection | DOAJ |
| description | Many rare yeasts are emerging as pathogens, causing invasive infections in susceptible hosts that are associated with poor clinical outcome. Here, we describe the first and fatal case of <i>Lodderomyces elongisporus</i> fungemia in a premature, extremely low-birth-weight neonate after spontaneous vaginal delivery. The bloodstream isolate was identified as <i>C. parapsilosis</i> by the VITEK 2 yeast identification system and as <i>L. elongisporus</i> by PCR-sequencing of the internal transcribed spacer (ITS) region of ribosomal DNA. Antifungal susceptibility testing data for the isolate, performed by the broth microdilution-based MICRONAUT-AM assay, showed susceptibility to all nine antifungal drugs tested. Despite the initiation of treatment with liposomal amphotericin B, the patient died on the same day that the blood culture yielded yeast growth. This is the first report of <i>L. elongisporus</i> bloodstream infection in a neonate as the previous nine cases reported in the literature occurred in adult patients. The crude mortality rate for invasive <i>L. elongisporus</i> infection is 50%, as only 5 of 10 patients survived. |
| first_indexed | 2024-03-09T23:31:24Z |
| format | Article |
| id | doaj.art-ac3935b3e725433297fc9449b7031829 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T23:31:24Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-ac3935b3e725433297fc9449b70318292023-11-23T17:09:02ZengMDPI AGJournal of Fungi2309-608X2022-08-018990610.3390/jof8090906Fatal <i>Lodderomyces elongisporus</i> Fungemia in a Premature, Extremely Low-Birth-Weight NeonateMohammad Asadzadeh0Noura Al-Sweih1Suhail Ahmad2Seema Khan3Wadha Alfouzan4Leena Joseph5Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya 46300, KuwaitDepartment of Microbiology, Faculty of Medicine, Kuwait University, Jabriya 46300, KuwaitDepartment of Microbiology, Faculty of Medicine, Kuwait University, Jabriya 46300, KuwaitMicrobiology Department, Maternity Hospital, Shuwaikh 70031, KuwaitDepartment of Microbiology, Faculty of Medicine, Kuwait University, Jabriya 46300, KuwaitDepartment of Microbiology, Faculty of Medicine, Kuwait University, Jabriya 46300, KuwaitMany rare yeasts are emerging as pathogens, causing invasive infections in susceptible hosts that are associated with poor clinical outcome. Here, we describe the first and fatal case of <i>Lodderomyces elongisporus</i> fungemia in a premature, extremely low-birth-weight neonate after spontaneous vaginal delivery. The bloodstream isolate was identified as <i>C. parapsilosis</i> by the VITEK 2 yeast identification system and as <i>L. elongisporus</i> by PCR-sequencing of the internal transcribed spacer (ITS) region of ribosomal DNA. Antifungal susceptibility testing data for the isolate, performed by the broth microdilution-based MICRONAUT-AM assay, showed susceptibility to all nine antifungal drugs tested. Despite the initiation of treatment with liposomal amphotericin B, the patient died on the same day that the blood culture yielded yeast growth. This is the first report of <i>L. elongisporus</i> bloodstream infection in a neonate as the previous nine cases reported in the literature occurred in adult patients. The crude mortality rate for invasive <i>L. elongisporus</i> infection is 50%, as only 5 of 10 patients survived.https://www.mdpi.com/2309-608X/8/9/906<i>Lodderomyces elongisporus</i><i>Candida parapsilosis</i> complexfungemiaextremely low-birth-weight neonateneonatal intensive care unit (NICU) |
| spellingShingle | Mohammad Asadzadeh Noura Al-Sweih Suhail Ahmad Seema Khan Wadha Alfouzan Leena Joseph Fatal <i>Lodderomyces elongisporus</i> Fungemia in a Premature, Extremely Low-Birth-Weight Neonate Journal of Fungi <i>Lodderomyces elongisporus</i> <i>Candida parapsilosis</i> complex fungemia extremely low-birth-weight neonate neonatal intensive care unit (NICU) |
| title | Fatal <i>Lodderomyces elongisporus</i> Fungemia in a Premature, Extremely Low-Birth-Weight Neonate |
| title_full | Fatal <i>Lodderomyces elongisporus</i> Fungemia in a Premature, Extremely Low-Birth-Weight Neonate |
| title_fullStr | Fatal <i>Lodderomyces elongisporus</i> Fungemia in a Premature, Extremely Low-Birth-Weight Neonate |
| title_full_unstemmed | Fatal <i>Lodderomyces elongisporus</i> Fungemia in a Premature, Extremely Low-Birth-Weight Neonate |
| title_short | Fatal <i>Lodderomyces elongisporus</i> Fungemia in a Premature, Extremely Low-Birth-Weight Neonate |
| title_sort | fatal i lodderomyces elongisporus i fungemia in a premature extremely low birth weight neonate |
| topic | <i>Lodderomyces elongisporus</i> <i>Candida parapsilosis</i> complex fungemia extremely low-birth-weight neonate neonatal intensive care unit (NICU) |
| url | https://www.mdpi.com/2309-608X/8/9/906 |
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