A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders
Abstract Long non-coding RNA papillary thyroid carcinoma susceptibility candidate 3 (LncRNA PTCSC3) is located on human chromosome 14q13.3. PTCSC3 functions as a tumor suppressor lncRNA to regulate essential cellular processes such as apoptosis, cell proliferation, migration, invasion, angiogenesis,...
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Format: | Article |
Language: | English |
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BMC
2023-08-01
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Series: | Cancer Cell International |
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Online Access: | https://doi.org/10.1186/s12935-023-03037-y |
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author | Majid Ghasemian Jafar Poodineh |
author_facet | Majid Ghasemian Jafar Poodineh |
author_sort | Majid Ghasemian |
collection | DOAJ |
description | Abstract Long non-coding RNA papillary thyroid carcinoma susceptibility candidate 3 (LncRNA PTCSC3) is located on human chromosome 14q13.3. PTCSC3 functions as a tumor suppressor lncRNA to regulate essential cellular processes such as apoptosis, cell proliferation, migration, invasion, angiogenesis, and epithelial-to-mesenchymal transition. PTCSC3 is also involved in the regulation of the Wnt/β-catenin signaling pathway, aerobic glycolysis, and p53 pathways. Downregulation of PTCSC3 has been associated with an increased risk of many tumors such as thyroid, gastric, laryngeal, breast, cervical, oral, lung, and glioma cancers. In addition, dysregulation of PTCSC3 has been reported in non-cancerous disorders notably osteoporosis and periodontitis. However, a number of single nucleotide polymorphisms at PTCSC3 have been linked to a higher risk of human diseases. This literature review summarizes the diagnostic, prognostic, and the clinical value of abnormal expression of PTCSC3 in cancerous and non-cancerous disorders and comprehensively analyzes potential molecular regulatory mechanism related to PTCSC3, which is expected to provide clear guidance for future PTCSC3 research. |
first_indexed | 2024-03-10T17:00:10Z |
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id | doaj.art-ac3941897d6f4a43b6b938da506067a0 |
institution | Directory Open Access Journal |
issn | 1475-2867 |
language | English |
last_indexed | 2024-03-10T17:00:10Z |
publishDate | 2023-08-01 |
publisher | BMC |
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series | Cancer Cell International |
spelling | doaj.art-ac3941897d6f4a43b6b938da506067a02023-11-20T10:59:43ZengBMCCancer Cell International1475-28672023-08-012311810.1186/s12935-023-03037-yA review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disordersMajid Ghasemian0Jafar Poodineh1Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical SciencesPediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical SciencesAbstract Long non-coding RNA papillary thyroid carcinoma susceptibility candidate 3 (LncRNA PTCSC3) is located on human chromosome 14q13.3. PTCSC3 functions as a tumor suppressor lncRNA to regulate essential cellular processes such as apoptosis, cell proliferation, migration, invasion, angiogenesis, and epithelial-to-mesenchymal transition. PTCSC3 is also involved in the regulation of the Wnt/β-catenin signaling pathway, aerobic glycolysis, and p53 pathways. Downregulation of PTCSC3 has been associated with an increased risk of many tumors such as thyroid, gastric, laryngeal, breast, cervical, oral, lung, and glioma cancers. In addition, dysregulation of PTCSC3 has been reported in non-cancerous disorders notably osteoporosis and periodontitis. However, a number of single nucleotide polymorphisms at PTCSC3 have been linked to a higher risk of human diseases. This literature review summarizes the diagnostic, prognostic, and the clinical value of abnormal expression of PTCSC3 in cancerous and non-cancerous disorders and comprehensively analyzes potential molecular regulatory mechanism related to PTCSC3, which is expected to provide clear guidance for future PTCSC3 research.https://doi.org/10.1186/s12935-023-03037-yPTCSC3CancerThyroidSignaling pathwayTumor suppressor |
spellingShingle | Majid Ghasemian Jafar Poodineh A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders Cancer Cell International PTCSC3 Cancer Thyroid Signaling pathway Tumor suppressor |
title | A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders |
title_full | A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders |
title_fullStr | A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders |
title_full_unstemmed | A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders |
title_short | A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders |
title_sort | review on the biological roles of lncrna ptcsc3 in cancerous and non cancerous disorders |
topic | PTCSC3 Cancer Thyroid Signaling pathway Tumor suppressor |
url | https://doi.org/10.1186/s12935-023-03037-y |
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