Innovative biomaterials for the treatment of periodontal disease
Periodontitis is a multifactorial disease that involves the destruction of hard and soft tissues surrounding the tooth. Routine periodontal treatment includes mechanical debridement (surgical and non-surgical) and the systemic administration of antibiotics. In contrast, severe and chronic periodonti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Dental Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2023.1163562/full |
| _version_ | 1797814161284005888 |
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| author | Yi Zhu Chen Tao Cynthia Goh Cynthia Goh Annie Shrestha Annie Shrestha Annie Shrestha |
| author_facet | Yi Zhu Chen Tao Cynthia Goh Cynthia Goh Annie Shrestha Annie Shrestha Annie Shrestha |
| author_sort | Yi Zhu |
| collection | DOAJ |
| description | Periodontitis is a multifactorial disease that involves the destruction of hard and soft tissues surrounding the tooth. Routine periodontal treatment includes mechanical debridement (surgical and non-surgical) and the systemic administration of antibiotics. In contrast, severe and chronic periodontitis involves aggressive tissue destruction and bone resorption, and the damage is usually irreversible. In these severe cases, bone grafts, the delivery of growth hormones, and guided tissue regeneration can all be used to stimulate periodontal regeneration. However, these approaches do not result in consistent and predictable treatment outcomes. As a result, advanced biomaterials have evolved as an adjunctive approach to improve clinical performance. These novel biomaterials are designed to either prolong the release of antibacterial agents or osteogenic molecules, or to act as immunomodulators to promote healing. The first half of this review briefly summarizes the key immune cells and their underlying cellular pathways implicated in periodontitis. Advanced biomaterials designed to promote periodontal regeneration will be highlighted in the second half. Finally, the limitations of the current experimental design and the challenges of translational science will be discussed. |
| first_indexed | 2024-03-13T08:03:29Z |
| format | Article |
| id | doaj.art-ac396fb1aea34455abf1b28867cdef69 |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2024-03-13T08:03:29Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-ac396fb1aea34455abf1b28867cdef692023-06-01T10:04:54ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152023-05-01410.3389/fdmed.2023.11635621163562Innovative biomaterials for the treatment of periodontal diseaseYi Zhu0Chen Tao1Cynthia Goh2Cynthia Goh3Annie Shrestha4Annie Shrestha5Annie Shrestha6Faculty of Dentistry, University of Toronto, Toronto, ON, CanadaStomatological Hospital of Chongqing, Key Laboratory of Oral Diseases and Biomaterial Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, ChinaDepartment of Chemistry, University of Toronto, Toronto, ON, CanadaDepartment of Materials Science and Engineering, University of Toronto, Toronto, ON, CanadaFaculty of Dentistry, University of Toronto, Toronto, ON, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CanadaDepartment of Dentistry, Mt. Sinai Hospital, Toronto, ON, CanadaPeriodontitis is a multifactorial disease that involves the destruction of hard and soft tissues surrounding the tooth. Routine periodontal treatment includes mechanical debridement (surgical and non-surgical) and the systemic administration of antibiotics. In contrast, severe and chronic periodontitis involves aggressive tissue destruction and bone resorption, and the damage is usually irreversible. In these severe cases, bone grafts, the delivery of growth hormones, and guided tissue regeneration can all be used to stimulate periodontal regeneration. However, these approaches do not result in consistent and predictable treatment outcomes. As a result, advanced biomaterials have evolved as an adjunctive approach to improve clinical performance. These novel biomaterials are designed to either prolong the release of antibacterial agents or osteogenic molecules, or to act as immunomodulators to promote healing. The first half of this review briefly summarizes the key immune cells and their underlying cellular pathways implicated in periodontitis. Advanced biomaterials designed to promote periodontal regeneration will be highlighted in the second half. Finally, the limitations of the current experimental design and the challenges of translational science will be discussed.https://www.frontiersin.org/articles/10.3389/fdmed.2023.1163562/fullperiodontitisinjectable hydrogelbiomaterialsimmune modulationbone regeneration |
| spellingShingle | Yi Zhu Chen Tao Cynthia Goh Cynthia Goh Annie Shrestha Annie Shrestha Annie Shrestha Innovative biomaterials for the treatment of periodontal disease Frontiers in Dental Medicine periodontitis injectable hydrogel biomaterials immune modulation bone regeneration |
| title | Innovative biomaterials for the treatment of periodontal disease |
| title_full | Innovative biomaterials for the treatment of periodontal disease |
| title_fullStr | Innovative biomaterials for the treatment of periodontal disease |
| title_full_unstemmed | Innovative biomaterials for the treatment of periodontal disease |
| title_short | Innovative biomaterials for the treatment of periodontal disease |
| title_sort | innovative biomaterials for the treatment of periodontal disease |
| topic | periodontitis injectable hydrogel biomaterials immune modulation bone regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2023.1163562/full |
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