Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses
This study systematically analyzes the association between interleukin-18 (IL-18) gene polymorphisms and rheumatoid arthritis (RA) susceptibility. The electronic databases Ovid MEDLINE, Ovid Excerpta Medica Database, and Cochrane Library were searched to identify meta-analyses that included case–con...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2024/6631033 |
| _version_ | 1797321110703833088 |
|---|---|
| author | Yuehong Chen Yali Ye Huan Liu Zhongling Luo Qianwei Li Qibing Xie |
| author_facet | Yuehong Chen Yali Ye Huan Liu Zhongling Luo Qianwei Li Qibing Xie |
| author_sort | Yuehong Chen |
| collection | DOAJ |
| description | This study systematically analyzes the association between interleukin-18 (IL-18) gene polymorphisms and rheumatoid arthritis (RA) susceptibility. The electronic databases Ovid MEDLINE, Ovid Excerpta Medica Database, and Cochrane Library were searched to identify meta-analyses that included case–control studies reporting IL-18 gene polymorphisms and RA susceptibility. Data were reanalyzed using Review Manager Software 5.1, and Mantel–Haenszel random effects were applied for the five genetic models: allelic, recessive, dominant, homozygote, and heterozygote. The effect size of odds ratios (ORs) and their corresponding 95% confidence interval (CI) were calculated. A total of seven meta-analyses with poor quality were included. The IL-18 polymorphisms -607 A/C, -137 C/G, -920 T/C, and -105 C/A have been reported. With weak evidence, IL-18 -607 A/C polymorphisms were associated with a reduced risk of RA susceptibility using the allele model (OR = 0.76, 95% CI: 0.61 − 0.93, p=0.01), dominant model (OR = 0.67, 95% CI: 0.50 − 0.90, p=0.008), homozygote model (OR = 0.57, 95% CI: 0.35 − 0.91, p=0.02), and heterozygote model (OR = 0.71, 95% CI: 0.54 − 0.93, p=0.01) in the overall population. IL-18 gene polymorphisms and RA susceptibility are affected by ethnicity: With weak evidence, IL-18 -137 C/G polymorphisms were related to reduce RA susceptibility in the Asian population (allele model: OR = 0.59, 95% CI: 0.40 − 0.88, p=0.01; dominant model: OR = 0.57, 95% CI: 0.37 − 0.89, p=0.01; heterozygote model: OR = 0.60, 95% CI: 0.38 − 0.94, p=0.03). IL-18 -607 A/C gene polymorphisms are a protective factor for RA susceptibility in the overall population, and IL-18 −137 C/G gene polymorphisms are a protective factor for RA susceptibility in the Asian population. Further studies are needed to confirm these results owing to the limitations of the included studies. |
| first_indexed | 2024-03-08T04:52:48Z |
| format | Article |
| id | doaj.art-ac3a3da2fcda441384df7a51ba97fb04 |
| institution | Directory Open Access Journal |
| issn | 2314-7156 |
| language | English |
| last_indexed | 2024-03-08T04:52:48Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj.art-ac3a3da2fcda441384df7a51ba97fb042024-02-08T00:00:17ZengHindawi LimitedJournal of Immunology Research2314-71562024-01-01202410.1155/2024/6631033Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-AnalysesYuehong Chen0Yali Ye1Huan Liu2Zhongling Luo3Qianwei Li4Qibing Xie5Department of Rheumatology and ImmunologyDepartment of Rheumatology and ImmunologyDepartment of Rheumatology and ImmunologyDepartment of Rheumatology and ImmunologyDepartment of Rheumatology and ImmunologyDepartment of Rheumatology and ImmunologyThis study systematically analyzes the association between interleukin-18 (IL-18) gene polymorphisms and rheumatoid arthritis (RA) susceptibility. The electronic databases Ovid MEDLINE, Ovid Excerpta Medica Database, and Cochrane Library were searched to identify meta-analyses that included case–control studies reporting IL-18 gene polymorphisms and RA susceptibility. Data were reanalyzed using Review Manager Software 5.1, and Mantel–Haenszel random effects were applied for the five genetic models: allelic, recessive, dominant, homozygote, and heterozygote. The effect size of odds ratios (ORs) and their corresponding 95% confidence interval (CI) were calculated. A total of seven meta-analyses with poor quality were included. The IL-18 polymorphisms -607 A/C, -137 C/G, -920 T/C, and -105 C/A have been reported. With weak evidence, IL-18 -607 A/C polymorphisms were associated with a reduced risk of RA susceptibility using the allele model (OR = 0.76, 95% CI: 0.61 − 0.93, p=0.01), dominant model (OR = 0.67, 95% CI: 0.50 − 0.90, p=0.008), homozygote model (OR = 0.57, 95% CI: 0.35 − 0.91, p=0.02), and heterozygote model (OR = 0.71, 95% CI: 0.54 − 0.93, p=0.01) in the overall population. IL-18 gene polymorphisms and RA susceptibility are affected by ethnicity: With weak evidence, IL-18 -137 C/G polymorphisms were related to reduce RA susceptibility in the Asian population (allele model: OR = 0.59, 95% CI: 0.40 − 0.88, p=0.01; dominant model: OR = 0.57, 95% CI: 0.37 − 0.89, p=0.01; heterozygote model: OR = 0.60, 95% CI: 0.38 − 0.94, p=0.03). IL-18 -607 A/C gene polymorphisms are a protective factor for RA susceptibility in the overall population, and IL-18 −137 C/G gene polymorphisms are a protective factor for RA susceptibility in the Asian population. Further studies are needed to confirm these results owing to the limitations of the included studies.http://dx.doi.org/10.1155/2024/6631033 |
| spellingShingle | Yuehong Chen Yali Ye Huan Liu Zhongling Luo Qianwei Li Qibing Xie Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses Journal of Immunology Research |
| title | Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses |
| title_full | Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses |
| title_fullStr | Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses |
| title_full_unstemmed | Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses |
| title_short | Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses |
| title_sort | interleukin 18 gene polymorphisms and rheumatoid arthritis susceptibility an umbrella review of meta analyses |
| url | http://dx.doi.org/10.1155/2024/6631033 |
| work_keys_str_mv | AT yuehongchen interleukin18genepolymorphismsandrheumatoidarthritissusceptibilityanumbrellareviewofmetaanalyses AT yaliye interleukin18genepolymorphismsandrheumatoidarthritissusceptibilityanumbrellareviewofmetaanalyses AT huanliu interleukin18genepolymorphismsandrheumatoidarthritissusceptibilityanumbrellareviewofmetaanalyses AT zhonglingluo interleukin18genepolymorphismsandrheumatoidarthritissusceptibilityanumbrellareviewofmetaanalyses AT qianweili interleukin18genepolymorphismsandrheumatoidarthritissusceptibilityanumbrellareviewofmetaanalyses AT qibingxie interleukin18genepolymorphismsandrheumatoidarthritissusceptibilityanumbrellareviewofmetaanalyses |