Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG
Hypertriglyceridemia (HTG) is associated with insulin resistance, increased cholesteryl ester transfer (CET), and low HDL cholesterol. Phospholipid transfer protein (PLTP) may be involved in these relationships. Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP...
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| Format: | Article |
| Language: | English |
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Elsevier
2003-08-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520337548 |
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| author | Iris J.A.M. Jonkers Augustinus H.M. Smelt Hiroaki Hattori Leo M. Scheek Teus van Gent Frits H.A.F. de Man Arnoud van der Laarse Arie van Tol |
| author_facet | Iris J.A.M. Jonkers Augustinus H.M. Smelt Hiroaki Hattori Leo M. Scheek Teus van Gent Frits H.A.F. de Man Arnoud van der Laarse Arie van Tol |
| author_sort | Iris J.A.M. Jonkers |
| collection | DOAJ |
| description | Hypertriglyceridemia (HTG) is associated with insulin resistance, increased cholesteryl ester transfer (CET), and low HDL cholesterol. Phospholipid transfer protein (PLTP) may be involved in these relationships. Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. Effects of 6 weeks of bezafibrate treatment were studied in HTG patients. HTG patients had higher serum triglycerides, insulin resistance, free fatty acid (FFA), and CET, lower levels of HDL cholesterol (−44%) and PLTP mass (−54%), and higher CETP (+20%) and PLTP activity (+48%) than controls. Bezafibrate reduced triglycerides, CET (−37%), insulin resistance (−53%), FFA (−48%), CETP activity (−12%), PLTP activity (−8%), and increased HDL cholesterol (+27%), whereas PLTP mass remained unchanged. Regression analysis showed a positive contribution of PLTP mass (P = 0.001) but not of PLTP activity to HDL cholesterol, whereas insulin resistance positively contributed to PLTP activity (P < 0.01). Bezafibrate-induced change in CET and HDL cholesterol correlated with changes in CETP activity and FFAs, but not with change in PLTP activity. Bezafibrate-induced change in PLTP activity correlated with change in FFAs (r = 0.455, P = 0.058). We propose that elevated PLTP activity in HTG is related to insulin resistance and not to increased PLTP mass.Bezafibrate-induced diminished insulin resistance is associated with a reduction of CET and PLTP activity. |
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| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T07:23:55Z |
| publishDate | 2003-08-01 |
| publisher | Elsevier |
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| series | Journal of Lipid Research |
| spelling | doaj.art-ac3d8c0f5eed4142840cb5cba995a5372022-12-21T21:58:41ZengElsevierJournal of Lipid Research0022-22752003-08-0144814621469Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTGIris J.A.M. Jonkers0Augustinus H.M. Smelt1Hiroaki Hattori2Leo M. Scheek3Teus van Gent4Frits H.A.F. de Man5Arnoud van der Laarse6Arie van Tol7Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Research Division, R&D Center, BML, Inc., 1361-1 Matoba, Kawagoe, Saitama, Japan; Department of Biochemistry, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Research Division, R&D Center, BML, Inc., 1361-1 Matoba, Kawagoe, Saitama, Japan; Department of Biochemistry, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Research Division, R&D Center, BML, Inc., 1361-1 Matoba, Kawagoe, Saitama, Japan; Department of Biochemistry, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Research Division, R&D Center, BML, Inc., 1361-1 Matoba, Kawagoe, Saitama, Japan; Department of Biochemistry, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Research Division, R&D Center, BML, Inc., 1361-1 Matoba, Kawagoe, Saitama, Japan; Department of Biochemistry, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Research Division, R&D Center, BML, Inc., 1361-1 Matoba, Kawagoe, Saitama, Japan; Department of Biochemistry, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Research Division, R&D Center, BML, Inc., 1361-1 Matoba, Kawagoe, Saitama, Japan; Department of Biochemistry, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Research Division, R&D Center, BML, Inc., 1361-1 Matoba, Kawagoe, Saitama, Japan; Department of Biochemistry, Erasmus Medical Center, Rotterdam, The NetherlandsHypertriglyceridemia (HTG) is associated with insulin resistance, increased cholesteryl ester transfer (CET), and low HDL cholesterol. Phospholipid transfer protein (PLTP) may be involved in these relationships. Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. Effects of 6 weeks of bezafibrate treatment were studied in HTG patients. HTG patients had higher serum triglycerides, insulin resistance, free fatty acid (FFA), and CET, lower levels of HDL cholesterol (−44%) and PLTP mass (−54%), and higher CETP (+20%) and PLTP activity (+48%) than controls. Bezafibrate reduced triglycerides, CET (−37%), insulin resistance (−53%), FFA (−48%), CETP activity (−12%), PLTP activity (−8%), and increased HDL cholesterol (+27%), whereas PLTP mass remained unchanged. Regression analysis showed a positive contribution of PLTP mass (P = 0.001) but not of PLTP activity to HDL cholesterol, whereas insulin resistance positively contributed to PLTP activity (P < 0.01). Bezafibrate-induced change in CET and HDL cholesterol correlated with changes in CETP activity and FFAs, but not with change in PLTP activity. Bezafibrate-induced change in PLTP activity correlated with change in FFAs (r = 0.455, P = 0.058). We propose that elevated PLTP activity in HTG is related to insulin resistance and not to increased PLTP mass.Bezafibrate-induced diminished insulin resistance is associated with a reduction of CET and PLTP activity.http://www.sciencedirect.com/science/article/pii/S0022227520337548phospholipid transfer proteincholesteryl ester transfertriglycerideshypertriglyceridemia |
| spellingShingle | Iris J.A.M. Jonkers Augustinus H.M. Smelt Hiroaki Hattori Leo M. Scheek Teus van Gent Frits H.A.F. de Man Arnoud van der Laarse Arie van Tol Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG Journal of Lipid Research phospholipid transfer protein cholesteryl ester transfer triglycerides hypertriglyceridemia |
| title | Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG |
| title_full | Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG |
| title_fullStr | Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG |
| title_full_unstemmed | Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG |
| title_short | Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG |
| title_sort | decreased pltp mass but elevated pltp activity linked to insulin resistance in htg |
| topic | phospholipid transfer protein cholesteryl ester transfer triglycerides hypertriglyceridemia |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520337548 |
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