Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives
Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/2862 |
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| author | Batoul Abi Zamer Waseem El-Huneidi Mohamed Ahmed Eladl Jibran Sualeh Muhammad |
| author_facet | Batoul Abi Zamer Waseem El-Huneidi Mohamed Ahmed Eladl Jibran Sualeh Muhammad |
| author_sort | Batoul Abi Zamer |
| collection | DOAJ |
| description | Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels, but their expression upregulates in response to a wide variety of insults, including anticancer drugs, allowing cancer cells to develop chemoresistance. In recent years, several researchers have reported that HSPs could be an important therapeutic target in difficult-to-treat cancers such as colorectal carcinoma (CRC). Worldwide, CRC is the second most common type of cancer and the second leading cause of cancer-related deaths. The molecular complexity of CRC and the coexisting inflammatory conditions present a significant obstacle to developing effective treatment. Recently, considerable progress has been made in enhancing our understanding of the role of HSPs in CRC pathogenesis. Moreover, novel therapeutic strategies targeting HSPs, either alone or in combination with other anticancer agents, have been reported. Herein, we present an overview of the functional mechanisms and the diagnostic and prognostic potential of HSPs in CRC. We also discuss emerging anti-CRC strategies based on targeting HSPs. |
| first_indexed | 2024-03-10T05:37:38Z |
| format | Article |
| id | doaj.art-ac3dd17d7b0043809401c20d1231e5d5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:38Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ac3dd17d7b0043809401c20d1231e5d52023-11-22T22:47:50ZengMDPI AGCells2073-44092021-10-011011286210.3390/cells10112862Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic PerspectivesBatoul Abi Zamer0Waseem El-Huneidi1Mohamed Ahmed Eladl2Jibran Sualeh Muhammad3Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab EmiratesDepartment of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab EmiratesDepartment of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab EmiratesDepartment of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab EmiratesCancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels, but their expression upregulates in response to a wide variety of insults, including anticancer drugs, allowing cancer cells to develop chemoresistance. In recent years, several researchers have reported that HSPs could be an important therapeutic target in difficult-to-treat cancers such as colorectal carcinoma (CRC). Worldwide, CRC is the second most common type of cancer and the second leading cause of cancer-related deaths. The molecular complexity of CRC and the coexisting inflammatory conditions present a significant obstacle to developing effective treatment. Recently, considerable progress has been made in enhancing our understanding of the role of HSPs in CRC pathogenesis. Moreover, novel therapeutic strategies targeting HSPs, either alone or in combination with other anticancer agents, have been reported. Herein, we present an overview of the functional mechanisms and the diagnostic and prognostic potential of HSPs in CRC. We also discuss emerging anti-CRC strategies based on targeting HSPs.https://www.mdpi.com/2073-4409/10/11/2862heat shock proteinscolorectal carcinomachaperonestheranostics |
| spellingShingle | Batoul Abi Zamer Waseem El-Huneidi Mohamed Ahmed Eladl Jibran Sualeh Muhammad Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives Cells heat shock proteins colorectal carcinoma chaperones theranostics |
| title | Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives |
| title_full | Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives |
| title_fullStr | Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives |
| title_full_unstemmed | Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives |
| title_short | Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives |
| title_sort | ins and outs of heat shock proteins in colorectal carcinoma its role in carcinogenesis and therapeutic perspectives |
| topic | heat shock proteins colorectal carcinoma chaperones theranostics |
| url | https://www.mdpi.com/2073-4409/10/11/2862 |
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